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Paula A. Velilla
Researcher at University of Antioquia
Publications - 57
Citations - 1828
Paula A. Velilla is an academic researcher from University of Antioquia. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 17, co-authored 50 publications receiving 1573 citations. Previous affiliations of Paula A. Velilla include University of Cincinnati Academic Health Center & Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation
Celine S. Lages,Isabelle Suffia,Paula A. Velilla,Bin Huang,Gregg A. Warshaw,David A. Hildeman,Yasmine Belkaid,Claire A. Chougnet +7 more
TL;DR: The increased proportion of Tregs in aged mice was associated with the spontaneous reactivation of chronic Leishmania major infection in old mice, likely because old TregS efficiently suppressed the production of IFN-γ by effector T cells.
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HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.
Jakob Nilsson,Adriano Boasso,Paula A. Velilla,Rui Zhang,Monica Vaccari,Genoveffa Franchini,Gene M. Shearer,Jan Andersson,Claire A. Chougnet +8 more
TL;DR: Exposure of Treg cells to HIV selectively promoted their survival via a CD4-gp120-dependent pathway, thus providing an underlying mechanism for the accumulation of TReg cells in infected hosts with active viral replication.
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Defective antigen-presenting cell function in human neonates.
TL;DR: A review of what is known on the functionality of APC at birth and during early childhood suggests multiple factors could be involved in neonatal APC alteration, such as intrinsic immaturity, defective interaction between APCs and T cells and regulatory T-cell-mediated inhibition.
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Phenotypical characterization of regulatory T cells in humans and rodents.
TL;DR: The most common markers utilized for Treg typification by flow cytometry such as CD25, forkhead box protein 3 (FoxP3) and CD127 are revised and the expression of other molecules important for the phenotypical characterization of Treg cells are determined.
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Increased IFN-γ production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals
Carlos J. Montoya,Paula A. Velilla,Claire A. Chougnet,Claire A. Chougnet,Alan L. Landay,María Teresa Rugeles +5 more
TL;DR: The results suggest that IFN-gamma production by innate immune cells might be one of the multiple factors involved in controlling the establishment of sexually transmitted HIV-1 infection.