P
Pamela A. Reid
Researcher at University of Dundee
Publications - 11
Citations - 772
Pamela A. Reid is an academic researcher from University of Dundee. The author has contributed to research in topics: Major histocompatibility complex & Antigen. The author has an hindex of 7, co-authored 11 publications receiving 763 citations. Previous affiliations of Pamela A. Reid include University of Glasgow.
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Journal ArticleDOI
Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments
Pamela A. Reid,Colin Watts +1 more
TL;DR: Show by using new cleavable labelling reagents that class II and class I MHC on B lymphoblastoid cells are continually endocytosed and recycled to the cell surface and reveal a cycle that might explain the rapid binding and turnover of some peptide/class II MHC complexes and the exchange of pre-existing for new peptides observed in living cells.
Journal ArticleDOI
Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes
TL;DR: Using a lectin-binding assay, it is shown that physiological processing products bind to the newly maturing population of MHC molecules rather than binding to the preexisting cell surface population; in contrast, an exogenous peptide binds predominantly to the latter population.
Journal ArticleDOI
Irreversible association of peptides with class II MHC molecules in living cells
TL;DR: The half- life of peptide/class II complexes in human antigen-presenting cells is found to be very similar to the half-life of class II molecules themselves, indicating that peptides are bound irreversibly under physiological conditions.
Journal Article
Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation.
J. J. Gilbert,Allison Stewart,C.-A. Courtney,M.-C. Fleming,Pamela A. Reid,C. G. Jackson,Amy Wise,Michael J.O. Wakelam,Margaret M. Harnett +8 more
TL;DR: Western blot analysis and data suggest that cPLA2 does not play a role in Ag receptor-mediated lymphocyte activation, but may be involved in the molecular mechanisms underlying lymphocyte maturation and/or self tolerance by clonal deletion.
Journal Article
Constitutive endocytosis and recycling of major histocompatibility complex class II glycoproteins in human B-lymphoblastoid cells.
Pamela A. Reid,Colin Watts +1 more
TL;DR: Results suggest that mature class II MHC molecules are constitutively endocytosed and recycled from acidic peripheral endosomes which may enhance their capacity to bind and present T cell epitopes which do not require processing.