H
Howard W. Davidson
Researcher at University of Colorado Denver
Publications - 90
Citations - 6424
Howard W. Davidson is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 39, co-authored 89 publications receiving 6004 citations. Previous affiliations of Howard W. Davidson include University of Dundee & Anschutz Medical Campus.
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Journal ArticleDOI
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Janet M. Wenzlau,Kirstine Juhl,Kirstine Juhl,Liping Yu,Ong Moua,Suparna A. Sarkar,Peter A. Gottlieb,Marian Rewers,George S. Eisenbarth,Jan Jensen,Howard W. Davidson,John C. Hutton +11 more
TL;DR: The combined measurement of ZnT8A, GADA, IA2A, and IAA raised autoimmunity detection rates to 98% at disease onset, a level that approaches that needed to detect prediabetes in a general pediatric population.
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Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
Otilia V. Vieira,Otilia V. Vieira,Roberto J. Botelho,Lucia E. Rameh,Saskia M. Brachmann,Saskia M. Brachmann,Tsuyoshi Matsuo,Howard W. Davidson,Alan D. Schreiber,Jonathan M. Backer,Lewis C. Cantley,Sergio Grinstein +11 more
TL;DR: It is found that phosphatidylinositol 3-phosphate (PI[3]P) accumulates greatly but transiently on the phagosomal membrane, and the possibility that PI(3)P production by VPS34 may be targeted during the maturation arrest induced by some intracellular parasites is raised.
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases
TL;DR: The results suggest a simple mechanism whereby different dibasic sites can be cleaved in different cellular compartments, and how proteolytic conversion of diverse proproteins destined for different cellular sites can occur differentially and in a regulated manner is suggested.
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A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments.
TL;DR: The function of a mutant (rab1a[S25N]) containing a substitution which perturbs Mg2+ coordination and reduces the affinity for GTP is analyzed, resulting in a form which is likely to be restricted to the GDP-bound state.
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Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartment.
TL;DR: These studies demonstrate that digitonin permeabilized cells can be used to efficiently reconstitute the early secretory pathway in vitro, allowing a direct comparison of the morphological and biochemical events involved in vesicular tafficking, and identifying a key role for the p58 containing compartment in ER to Golgi transport.