P
Pamela J. Mitchell
Researcher at Pennsylvania State University
Publications - 32
Citations - 9592
Pamela J. Mitchell is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Transcription factor & Promoter. The author has an hindex of 26, co-authored 32 publications receiving 9434 citations. Previous affiliations of Pamela J. Mitchell include European Bioinformatics Institute & University of California, Berkeley.
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Journal ArticleDOI
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
Pamela J. Mitchell,Robert Tjian +1 more
TL;DR: This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors in mammalian DNA binding transcription factors.
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Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
TL;DR: It is demonstrated that multiple synthetic copies of the consensus AP-1-binding site can act as TPA-inducible enhancers in various plasmid constructs after transfection into HeLa cells, suggesting that AP- 1 is a transcription factor that functions by interacting with a specific enhancer element, and that its activities may be modulated by treatment of cells with TPA.
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Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen.
TL;DR: Sedimentation studies suggest that protein-protein interactions between AP-2 and T antigen block AP- 2 binding to DNA, suggesting novel mechanisms for mediating positive and negative regulation of transcription.
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Transcription factor AP-2 essential for cranial closure and craniofacial development
TL;DR: Failure of cranial closure between 9 and 9.5 days postcoitum coincided with increased apoptosis in the midbrain, anterior hindbrain and proximal mesenchyme of the first branchial arch, but did not involve loss of expression of twist or Pax-3, two other regulatory genes known to be required for Cranial closure.
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Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
TL;DR: This embryonic expression pattern is spatially and temporally consistent with a role for AP-2 in regulating transcription of genes involved in the morphogenesis of the peripheral nervous system, face, limbs, skin, and nephric tissues.