P
Pan Guo
Researcher at Third Military Medical University
Publications - 6
Citations - 757
Pan Guo is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Melatonin & Mitochondrion. The author has an hindex of 6, co-authored 6 publications receiving 595 citations.
Papers
More filters
Journal ArticleDOI
SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin
Huifeng Pi,Shangcheng Xu,Russel J. Reiter,Pan Guo,Lei Zhang,Yuming Li,Min Li,Zhenwang Cao,Li Tian,Jia Xie,Ruiqi Zhang,Mindi He,Yonghui Lu,Chuan Liu,Weixia Duan,Zhengping Yu,Zhou Zhou +16 more
TL;DR: Melatonin exerts a hepatoprotective effect on mitochondrial-derived O2•−-stimulated autophagic cell death that is dependent on the SIRT3/SOD2 pathway, and is reported to protect against Cd-induced hepatotoxicity.
Journal ArticleDOI
Dynamin 1-like-dependent mitochondrial fission initiates overactive mitophagy in the hepatotoxicity of cadmium.
Huifeng Pi,Shangcheng Xu,Lei Zhang,Pan Guo,Yuming Li,Jia Xie,Li Tian,Mindi He,Yonghui Lu,Min Li,Yanwen Zhang,Min Zhong,Yang Xiang,Linhong Deng,Zhou Zhou,Zhengping Yu +15 more
TL;DR: It is indicated that Cd induces mitochondrial loss via the overactivation of mitophagy following DNM1L-dependent mitochondrial fragmentation, and the balanced activity of D NM1L and mitophile signaling may be a potential therapeutic approach to treat Cd-induced hepatotoxicity.
Journal ArticleDOI
Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity
Shuangnian Xu,Huifeng Pi,Yueqi Chen,Ni-Xian Zhang,Pan Guo,Yonghui Lu,Mindi He,Jia Xie,Min Zhong,Yujun Zhang,Zubin Yu,Zhou Zhou +11 more
TL;DR: Manipulation of Drp1 may be the potential avenue for developing novel strategies to protect against cadmium-induced hepatotoxicity as indicated by the effects and underlying mechanism of Cd on mitochondrial dynamics during hepatot toxicity.
Journal ArticleDOI
Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria.
Shangcheng Xu,Huifeng Pi,Lei Zhang,Ni-Xian Zhang,Yuming Li,Huiliang Zhang,Ju Tang,Huijuan Li,Min Feng,Ping Deng,Pan Guo,Li Tian,Jia Xie,Mindi He,Yonghui Lu,Min Zhong,Yanwen Zhang,Wang Wang,Russel J. Reiter,Zhengping Yu,Zhou Zhou +20 more
TL;DR: These results are the first to demonstrate that abnormal mitochondrial dynamics is involved in cadmium‐induced neurotoxicity and that Melatonin has significant pharmacological potential in protecting against the neurotoxicity of Cd by blocking the disbalance of mitochondrial fusion and fission.
Journal ArticleDOI
Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro.
Pan Guo,Huifeng Pi,Shangcheng Xu,Lei Zhang,Yuming Li,Min Li,Zhengwang Cao,Li Tian,Jia Xie,Renyan Li,Mindi He,Yonghui Lu,Chuan Liu,Weixia Duan,Zhengping Yu,Zhou Zhou +15 more
TL;DR: SIRT1 plays an essential role in the ability of moderate melatonin to stimulate PGC-1 alpha and improve mitochondrial biogenesis and function at least partially through melatonin receptors in cadmium-induced hepatotoxicity, which indicates that Sirtinol and SIRT1 siRNA each blocked the melatonin-mediated elevation in mitochondrial function.