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Shuangnian Xu
Researcher at Third Military Medical University
Publications - 27
Citations - 706
Shuangnian Xu is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 17 publications receiving 515 citations.
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Journal ArticleDOI
Exposure to bisphenol A disrupts meiotic progression during spermatogenesis in adult rats through estrogen-like activity
Chuan Liu,Weixia Duan,Renyan Li,Shuangnian Xu,Lincheng Zhang,Chunhai Chen,Mindi He,Yonghui Lu,Hongjuan Wu,Huifeng Pi,Xue Luo,Yujun Zhang,Min Zhong,Zubin Yu,Zhou Zhou +14 more
TL;DR: The results suggest that ER signaling-mediated meiotic disruption may be a major contributor to the molecular events leading to BPA-related male reproductive disorders, and support the growing association between BPA exposure and the rapid increase in the incidence ofmale reproductive disorders.
Journal ArticleDOI
Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease.
Li Yin,Shuangnian Xu,Li Jc,Ke-qiang Han,Huifeng Pi,Lu Zheng,Guohua Zuo,Xin-Mei Huang,Li Huashun,Zhao Hongwen,Zubin Yu,Zhou Z,Ping Liang +12 more
TL;DR: The results demonstrate that the EMT has a role in promoting the blood-borne dissemination of primary HCC cells, and the twist and vimentin expression levels in CTCs could serve as promising biomarkers for evaluating metastasis and prognosis in HCC patients.
Journal ArticleDOI
Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity
Shuangnian Xu,Huifeng Pi,Yueqi Chen,Ni-Xian Zhang,Pan Guo,Yonghui Lu,Mindi He,Jia Xie,Min Zhong,Yujun Zhang,Zubin Yu,Zhou Zhou +11 more
TL;DR: Manipulation of Drp1 may be the potential avenue for developing novel strategies to protect against cadmium-induced hepatotoxicity as indicated by the effects and underlying mechanism of Cd on mitochondrial dynamics during hepatot toxicity.
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Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics
Xiangtao Huang,Xi Li,Mingling Xie,Zhen Huang,Yongxiu Huang,Guixian Wu,Zhi-rong Peng,Yanni Sun,Qian-liang Ming,Yan-xia Liu,Jieping Chen,Shuangnian Xu +11 more
TL;DR: This review summarized resveratrol's discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resver atrol as a potential drug candidate for anti-leukemia.
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MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
Mindi He,Yonghui Lu,Shuangnian Xu,Lin Mao,Lincheng Zhang,Weixia Duan,Chuan Liu,Huifeng Pi,Yujun Zhang,Min Zhong,Zubin Yu,Zhou Z +11 more
TL;DR: Investigation of miR-210 modulates alterations in energy metabolism after nickel exposure through suppressing ISCU1/2 and inactivating ISCs-containing metabolic enzymes determined that NiCl2 exposure leads to a significant accumulation of HIF-1α, rather than Hif-1β, in Neuro-2a cells.