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Shuangnian Xu

Researcher at Third Military Medical University

Publications -  27
Citations -  706

Shuangnian Xu is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 17 publications receiving 515 citations.

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Exposure to bisphenol A disrupts meiotic progression during spermatogenesis in adult rats through estrogen-like activity

TL;DR: The results suggest that ER signaling-mediated meiotic disruption may be a major contributor to the molecular events leading to BPA-related male reproductive disorders, and support the growing association between BPA exposure and the rapid increase in the incidence ofmale reproductive disorders.
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Epithelial-mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease.

TL;DR: The results demonstrate that the EMT has a role in promoting the blood-borne dissemination of primary HCC cells, and the twist and vimentin expression levels in CTCs could serve as promising biomarkers for evaluating metastasis and prognosis in HCC patients.
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Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity

TL;DR: Manipulation of Drp1 may be the potential avenue for developing novel strategies to protect against cadmium-induced hepatotoxicity as indicated by the effects and underlying mechanism of Cd on mitochondrial dynamics during hepatot toxicity.
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Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics

TL;DR: This review summarized resveratrol's discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resver atrol as a potential drug candidate for anti-leukemia.
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MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.

TL;DR: Investigation of miR-210 modulates alterations in energy metabolism after nickel exposure through suppressing ISCU1/2 and inactivating ISCs-containing metabolic enzymes determined that NiCl2 exposure leads to a significant accumulation of HIF-1α, rather than Hif-1β, in Neuro-2a cells.