Yujun Zhang

TL;DR: The data reveals that the pathway ‘HULC/USP22/Sirt1/ protective autophagy’ attenuates the sensitivity of HCC cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to HCC chemotherapy.

TL;DR: It is demonstrated that hypoxia-stabilized HIF1α promoted EMT through increasing SNAI1 transcription in HCC cells through increasing HIF-1α transcriptional regulated the expression of S NAI1 based on two Hypoxia response elements (HREs) in SNAi1 promoter.

TL;DR: It is found that high circ-PDE8A expression was correlated with lymphatic invasion, TNM stage and a poor survival rate of PDAC patients, and exosomal circ-PDE8A was associated with progression and prognosis in PDac patients.

TL;DR: Tumor generated exosomes could excrete to tumor cell or blood circulation in vivo condition and exosomal lncRNA Sox2ot plays important roles in tumor progression and may be a useful maker for pancreatic cancer prognosis.

TL;DR: The results suggest that ER signaling-mediated meiotic disruption may be a major contributor to the molecular events leading to BPA-related male reproductive disorders, and support the growing association between BPA exposure and the rapid increase in the incidence ofmale reproductive disorders.