P
Paolo De Los Rios
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 134
Citations - 5150
Paolo De Los Rios is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Protein folding & Chaperone (protein). The author has an hindex of 37, co-authored 124 publications receiving 4419 citations. Previous affiliations of Paolo De Los Rios include University of Lausanne & University of Fribourg.
Papers
More filters
Journal ArticleDOI
Understanding amyloid aggregation by statistical analysis of atomic force microscopy images
Jozef Adamcik,Jin-Mi Jung,Jérôme Flakowski,Paolo De Los Rios,Giovanni Dietler,Raffaele Mezzenga +5 more
TL;DR: It is shown that different stages of amyloid aggregation can be examined by performing a statistical polymer physics analysis of single-molecule atomic force microscopy images of heat-denatured beta-lactoglobulin fibrils.
Journal ArticleDOI
Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling
TL;DR: In this article, the entropy loss due to excluded volume effects is used to accelerate the local unfolding of various protein substrates and thus perform disparate cellular functions, such as protein disaggregation.
Journal ArticleDOI
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase
TL;DR: A stable, misfolded luciferase species that can be efficiently renatured by substoichiometric amounts of bacterial Hsp70-Hsp40-NEF is described and apparent V(max)' and K(m)' values for a chaperone-mediated renaturation reaction for the first time are determined.
Journal ArticleDOI
The mechanism of Hsp70 chaperones: (entropic) pulling the models together.
TL;DR: This work has proposed a unifying mechanism named 'entropic pulling', which proposed that Hsp70 uses the energy of ATP hydrolysis to recruit a force of entropic origin to locally unfold aggregates or pull proteins across membranes.
Journal ArticleDOI
Kosmotropes and chaotropes: modelling preferential exclusion, binding and aggregate stability.
TL;DR: The mechanism for these phenomena within an adapted version of the two-state Muller-Lee-Graziano model for water, which provides a complete description of the ternary water/cosolvent/solute system for small solute particles, is discussed.