P
Paolo Onori
Researcher at Sapienza University of Rome
Publications - 194
Citations - 6212
Paolo Onori is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Cholangiocyte & Cholangiocyte proliferation. The author has an hindex of 45, co-authored 175 publications receiving 5299 citations. Previous affiliations of Paolo Onori include University of L'Aquila & American Board of Legal Medicine.
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Journal ArticleDOI
Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages.
Guido Carpino,Vincenzo Cardinale,Paolo Onori,Antonio Franchitto,Pasquale Berloco,Massimo Rossi,Yunfang Wang,Rossella Semeraro,Maurizio M. Anceschi,Roberto Brunelli,Domenico Alvaro,Lola M. Reid,Eugenio Gaudio +12 more
TL;DR: The BTSCs are likely to be central to normal tissue turnover and injury repair and to be key elements in the pathophysiology of liver, pancreas and biliary tree diseases, including oncogenesis.
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Vascular Endothelial Growth Factor Stimulates Rat Cholangiocyte Proliferation Via an Autocrine Mechanism
Eugenio Gaudio,Barbara Barbaro,Barbara Barbaro,Domenico Alvaro,Shannon Glaser,Heather Francis,Yoshiyuki Ueno,Cynthia J. Meininger,Antonio Franchitto,Paolo Onori,Marco Marzioni,Silvia Taffetani,Giammarco Fava,George Stoica,Julie Venter,Ramona Reichenbach,Sharon De Morrow,Ryun Summers,Gianfranco Alpini +18 more
TL;DR: VEGF mediates the adaptive proliferative response of cholangiocytes to cholestasis and is found to be amplified in BDL cholangsiocytes.
Journal ArticleDOI
Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats.
Domenico Alvaro,Gianfranco Alpini,Paolo Onori,Lucia Perego,Gianluca Svegliati Baroni,Antonio Franchitto,Leonardo Baiocchi,Shannon Glaser,Gene Le Sage,Franco Folli,Eugenio Gaudio +10 more
TL;DR: This study suggests that estrogens and their receptors play a role in the modulation of cholangiocyte proliferation.
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Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD.
Guido Carpino,Maria Del Ben,Daniele Pastori,Roberto Carnevale,Francesco Baratta,Diletta Overi,Heather Francis,Vincenzo Cardinale,Paolo Onori,S. Safarikia,Vittoria Cammisotto,Domenico Alvaro,Gianluca Svegliati-Baroni,Francesco Angelico,Eugenio Gaudio,Francesco Violi +15 more
TL;DR: Lipopolysaccharides (LPS) is increased in nonalcoholic fatty liver disease (NAFLD), but its relationship with liver inflammation is not defined.
Journal ArticleDOI
Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma.
Domenico Alvaro,Barbara Barbaro,Antonio Franchitto,Paolo Onori,Shannon Glaser,Shannon Glaser,Gianfranco Alpini,Gianfranco Alpini,Heather Francis,Luca Marucci,Paola Sterpetti,S. Ginanni-Corradini,Andrea Onetti Muda,David E. Dostal,Adriano De Santis,Adolfo Francesco Attili,Antonio Benedetti,Eugenio Gaudio +17 more
TL;DR: It is shown that human intrahepatic cholangiocarcinomas express receptors for estrogens and IGF-1, which cooperate in the modulation of cell growth and apoptosis, and could represent a strategy for the management of cholangsiOCarcinoma.