S
Silvia Taffetani
Researcher at Texas A&M University System
Publications - 18
Citations - 1003
Silvia Taffetani is an academic researcher from Texas A&M University System. The author has contributed to research in topics: Hepatic stellate cell & Cholangiocyte. The author has an hindex of 12, co-authored 18 publications receiving 940 citations. Previous affiliations of Silvia Taffetani include Marche Polytechnic University.
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Journal ArticleDOI
Vascular Endothelial Growth Factor Stimulates Rat Cholangiocyte Proliferation Via an Autocrine Mechanism
Eugenio Gaudio,Barbara Barbaro,Barbara Barbaro,Domenico Alvaro,Shannon Glaser,Heather Francis,Yoshiyuki Ueno,Cynthia J. Meininger,Antonio Franchitto,Paolo Onori,Marco Marzioni,Silvia Taffetani,Giammarco Fava,George Stoica,Julie Venter,Ramona Reichenbach,Sharon De Morrow,Ryun Summers,Gianfranco Alpini +18 more
TL;DR: VEGF mediates the adaptive proliferative response of cholangiocytes to cholestasis and is found to be amplified in BDL cholangsiocytes.
Journal ArticleDOI
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
Marco Marzioni,Shannon Glaser,Heather Francis,Luca Marucci,Antonio Benedetti,Domenico Alvaro,Silvia Taffetani,Yoshiyuki Ueno,Tania Roskams,Jo Lynne Phinizy,J Venter,Giammarco Fava,Gene LeSage,Gianfranco Alpini,Gianfranco Alpini +14 more
TL;DR: The existence of an autocrine loop based on serotonin that limits the growth of the biliary tree in the course of chronic cholestasis is observed and might open new approaches for the management of cholangiopathies.
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Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production
Antonio Di Sario,Emanuele Bendia,Gianluca Svegliati Baroni,F. Ridolfi,Alessandro Casini,Elisabetta Ceni,Stefania Saccomanno,Marco Marzioni,Luciano Trozzi,Paola Sterpetti,Silvia Taffetani,Antonio Benedetti +11 more
TL;DR: Pirfenidone significantly inhibited PDGF-induced HSC proliferation, with a maximal effect at 1000 microM, without affecting HSC viability and without inducing apoptosis, and could be a new candidate for antifibrotic therapy in chronic liver diseases.
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cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.
Heather Francis,Shannon Glaser,Yoshiyuki Ueno,Gene LeSage,Luca Marucci,Antonio Benedetti,Silvia Taffetani,Marco Marzioni,Domenico Alvaro,Julie Venter,Ramona Reichenbach,Giammarco Fava,Jo Lynne Phinizy,Gianfranco Alpini,Gianfranco Alpini +14 more
TL;DR: Modulation of the PKA/Src/MEK/ERK1/2 pathway may be important in the regulation of cholangiocyte growth and secretion observed in cholestatic liver diseases.
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The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2
A. Di Sario,E. Bendia,Giampiero Macarri,Cinzia Candelaresi,Silvia Taffetani,Marco Marzioni,Alessia Omenetti,S. De Minicis,Luciano Trozzi,Angiolo Benedetti +9 more
TL;DR: The anti-fibrotic effect of pirfenidone is mainly due to the reduced expression of profibrogenic procollagen alpha1(I) and TIMP-1, most likely through the downregulation of transforming growth factorbeta1 mRNA, and of matrix metalloproteinase-2, which is mainly implicated in the degradation of the normal extracellular matrix.