Paolo Peretto

TL;DR: The data suggest that postnatal repeated maternal deprivation produces a significant reduction of BDNF expression within prefrontal cortex and striatum, which may render these structures less plastic and more vulnerable under challenging conditions.

TL;DR: The existence of a peculiar glial organization within the subependymal layer of the adult rat, consisting of long astrocytic tubes that likely represent a new type of glial guidance, accounting for the tangential migration of a high number of cells along their restricted pathway, to the olfactory bulb is demonstrated.

TL;DR: The subependymal layer is an area of the adult mammalian brain endowed with a cohort of phenomena proper of neural development, persisting into (and adapted to) the fully mature nervous tissue, an optimal model to unravel mechanisms permitting highly dynamic structural plasticity during adulthood.

TL;DR: A recent demonstration of high carnosine-like immunoreactivity in the subependymal layer of rodents, an area of the forebrain which shares with the olfactory neuroepithelium the occurrence of continuous neurogenesis during adulthood, supports the hypothesis that carnosin-related dipeptides could be implicated in some forms of structural plasticity.

TL;DR: Hochronic/heterochronic transplantation demonstrates that progenitor cells isolated from the LGE or SVZ at different stages engraft into the SVZ of neonatal or adult mice, migrate to the OB, and differentiate into local interneurons, including granule and periglomerular cells as well as other types of interneuronons.