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Paolo Preziosi
Researcher at The Catholic University of America
Publications - 115
Citations - 2805
Paolo Preziosi is an academic researcher from The Catholic University of America. The author has contributed to research in topics: Nitric oxide & Heme oxygenase. The author has an hindex of 29, co-authored 115 publications receiving 2690 citations. Previous affiliations of Paolo Preziosi include Sapienza University of Rome & University of Chieti-Pescara.
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Journal ArticleDOI
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium
Giorgio Minotti,Stefania Recalcati,Alvaro Mordente,Giovanni Liberi,Antonio M. Calafiore,Cesare Mancuso,Paolo Preziosi,Gaetano Cairo +7 more
TL;DR: It is demonstrated thatDOXol delocalizes low molecular weight Fe(II) from the [4Fe‐4S] cluster of cytoplasmic aconitase, suggesting that intramyocardial formation of DOXol may perturb the homeostatic processes associated with cluster assembly or disassembly and the reversible switch between acon itase and IRP‐1.
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Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: in vitro and in vivo studies in the rat.
Dello Russo C,Giuseppe Tringali,Enzo Ragazzoni,Nicola Maggiano,Menini E,Mauro Vairano,Paolo Preziosi,Pierluigi Navarra +7 more
TL;DR: The addition of NaHS to incubation media was consistently associated with a concentration‐dependent decrease in KCl‐stimulated CRH release, whereas basal secretion was unaffected, and SAMe showed no effect on hypothalamo‐pituitary‐adrenal (HPA) function under resting conditions, but inhibited stress‐related glucocorticoid increase.
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Isoniazid: metabolic aspects and toxicological correlates.
TL;DR: INH, HZ and its mono- and diacetylated metabolites, and ammonia are examined in terms of their potential to cause neurotoxic and hepatotoxic effects (the two major forms of INH toxicity observed in animals and humans).
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Erythropoietin exerts anti‐apoptotic effects on rat microglial cells in vitro
Mauro Vairano,Cinzia Dello Russo,Giacomo Pozzoli,Alessandra Battaglia,Giovanni Scambia,Giuseppe Tringali,Maria Antonietta Aloe-Spiriti,Paolo Preziosi,Pierluigi Navarra +8 more
TL;DR: The effects of EPO on primary cultures of rat cortical microglia and astrocytes are investigated and it is found that the cytokine increased microglial cell population size in a concentration‐dependent manner, but EPO did not affect the pro‐inflammatory function ofmicroglial cells.
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Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants.
Giacomo Pozzoli,Cesare Mancuso,Adriana Mirtella,Paolo Preziosi,A B Grossman,Pierluigi Navarra +5 more
TL;DR: Findings provide evidence that endogenous CO may play a role in the control of CRH release; by analogy with NO, CO may represent a major new neuroendocrine modulator.