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Paresh Dandona
Researcher at University at Buffalo
Publications - 646
Citations - 34629
Paresh Dandona is an academic researcher from University at Buffalo. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 91, co-authored 639 publications receiving 32575 citations. Previous affiliations of Paresh Dandona include Women & Children's Hospital of Buffalo & State University of New York System.
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Inflammation: the link between insulin resistance, obesity and diabetes.
TL;DR: The increased concentrations of TNF-alpha and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction, which might interfering with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
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Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity, Diabetes, and Inflammation
TL;DR: The original conceptualization of this syndrome was on the basis of resistance to the metabolic actions of insulin, and it was maintained that hyperinsulinemia itself contributes to atherogenicity, and thus, insulin is atherogenic, leading to the coronary heart disease and cerebrovascular disease associated with this syndrome.
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Procalcitonin increase after endotoxin injection in normal subjects.
Paresh Dandona,David E. Nix,Michael F. Wilson,Ahmad Aljada,John Love,Marcel Assicot,Claude Bohuon +6 more
TL;DR: It is concluded that endotoxin induces the release of procalcitonin systemically, that this increase is not associated with an increase in calcitonin, and that the increase in procalCitonin associated with septicemia in patients may be mediated through the effect of endotoxin described here.
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Oxidative damage to DNA in diabetes mellitus
Paresh Dandona,Kuldip Thusu,Stephen Cook,B.D. Snyder,J Makowski,D Armstrong,Thomas M. Nicotera +6 more
TL;DR: Diabetic patients showed greater oxidative damage to DNA, with increased generation of ROS, than controls, and such changes might contribute to accelerated aging and atherogenesis in diabetes and to the microangiopathic complications of the disease.
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Insulin Inhibits Intranuclear Nuclear Factor κB and Stimulates IκB in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect?
Paresh Dandona,Ahmad Aljada,Priya Mohanty,Husam Ghanim,Wael Hamouda,Ezzat Assian,Shakeel Ahmad +6 more
TL;DR: It is concluded that insulin has a potent acute anti-inflammatory effect including a reduction in intranuclear NFkappaB, an increase in Ikappa B, and decreases in ROS generation, p47(phox) subunit, plasma soluble intercellular adhesion molecule-1, monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor- 1 (PAI-1).