P
Parimala Nacharaju
Researcher at Albert Einstein College of Medicine
Publications - 44
Citations - 1152
Parimala Nacharaju is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Nitric oxide & Wound healing. The author has an hindex of 18, co-authored 44 publications receiving 1012 citations. Previous affiliations of Parimala Nacharaju include George Washington University.
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Degradation of tau by lysosomal enzyme cathepsin D: Implication for Alzheimer neurofibrillary degeneration
TL;DR: The results suggest that CD cleavage of tau could generate tau fragments with intact microtubule binding domains, which could have a role in the pathogenesis of paired helical filaments (PHFs) in Alzheimer's disease.
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Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice.
Karin Blecher,Karin Blecher,Luis R. Martinez,Luis R. Martinez,Chaim Tuckman-Vernon,Parimala Nacharaju,David Schairer,David Schairer,Jason Chouake,Jason Chouake,Joel M. Friedman,Alan A. Alfieri,Chandan Guha,Joshua D. Nosanchuk,Joshua D. Nosanchuk,Adam J. Friedman,Adam J. Friedman +16 more
TL;DR: This work demonstrates in a murine model that in these settings NO releasing nanoparticles significantly enhance wound healing, suggesting that NO-NPs may serve as a novel wound-healing therapy in the setting of immunocompromised states associated with impaired wound healing.
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Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide
TL;DR: No-np counteracted both systemic hypertension and decreased the vasoconstrictor effects of PBH infusion, improving systemic and microvascular function and has clear potential as a therapeutic agent to replenish NO in situations where NO production is impaired, insufficient, or consumed, thereby preventing vascular complications.
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Surface decoration of red blood cells with maleimidophenyl-polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells.
TL;DR: The surface decoration of red blood cells by polyethylene glycol (PEG) chains has been an approach developed to camouflage the blood group antigens from their antibodies to inhibit the agglutination of RBCs with the respective antibodies.
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Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing
Rabab A. Charafeddine,Joy Makdisi,David Schairer,Brian P. O’Rourke,Juan D. Diaz-Valencia,Jason Chouake,Allison Kutner,Aimee Krausz,Brandon L. Adler,Parimala Nacharaju,Hongying Liang,Suranjana Mukherjee,Joel M. Friedman,Adam J. Friedman,Joshua D. Nosanchuk,David J. Sharp +15 more
TL;DR: The previously uncharacterized microtubule-severing enzyme, Fidgetin-like 2 (FL2), is identified as a fundamental regulator of cell migration that can be targeted in vivo using nanoparticle-encapsulated small interfering RNA (siRNA) to promote wound closure and regeneration.