Showing papers in "Nanomedicine: Nanotechnology, Biology and Medicine in 2012"

TL;DR: A comprehensive review on the potential of nanotechnology in medicine focuses on different nanoparticulate drug-delivery systems including polymeric NPs, ceramic Nps, magnetic NPS, polymeric micelles and dendrimers as well as their applications in therapeutics, diagnostics and imaging.

TL;DR: Reasonable bactericidal activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus was demonstrated and the standard dilution micromethod determining the minimum inhibitory concentration leading to inhibition of bacterial growth was still under way.

TL;DR: Recent developments in the use of nanoparticles as drug delivery systems to treat a wide variety of diseases are reviewed and challenges and future nanotechnology strategies to overcome limitations are introduced.

TL;DR: This review is focused on tumor drug resistance-related properties of CSCs and describes current nanomedicine approaches, which could form the basis of novel combination therapies for eliminating metastatic and C SCs.

TL;DR: Evaluated the antibacterial activity of starch-stabilized AgNPs against a panel of human pathogens commonly associated with air, water and food borne infections and suggested Ag NPs as a promising template for the design of novel antibacterial agents.

TL;DR: This review examines the various techniques that are available to selectively target SPIONs toward a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics.

TL;DR: In this article, the effects of 24 nm silver nanoparticles (AgNPs) on a panel of bacteria isolated from medical devices used in a hospital intensive care unit were studied, and the authors demonstrated that 24 nm AgNPs were effective in suppressing the growth of clinically relevant bacteria with moderate to high levels of antibiotic resistance.

TL;DR: Curcumin-loaded γ-cyclodextrin liposomes were demonstrated in vitro to have significant potential as delivery vehicles for the treatment of cancers of mesenchymal and epithelial origin and differences between mechanisms of cell death were evaluated.

TL;DR: Recent advances regarding therapeutic efficacy, targeting and safety issues related to the application of mesoporous silica nanoparticles in cancer therapy are reported on.

TL;DR: A fluorescence-based, high-resolution flow cytometric method for quantitative and qualitative analysis of nanosized cell-derived membrane vesicles that are increasingly recognized both as therapeutic vehicles and high-potential biomarkers for several diseases is developed.

TL;DR: Owing to the versatility of nanoparticles, researchers envision the combination of multiple modalities to one carrier, which has been challenging due to the necessity of the adaptation of at least partially counteracting parameters between the different modalities.

TL;DR: Topically applied gold nanoparticles with epigallocatechin gallate and alpha-lipoic acid significantly accelerated mouse cutaneous wound healing through anti-inflammatory and antioxidation effects and may support future studies using other antioxidants in the treatment of cutaneous wounds.

TL;DR: Significant tumor-suppression effects, biocompatibility and efficient renal clearance are demonstrated in mesoporous silica nanoparticles used as chemotherapy delivering agents in two different human pancreatic cancer xenografts and different mouse species.

TL;DR: It is demonstrated that silica NPs promote a significant enhancement of bone mineral density (BMD) in mice in vivo, providing a proof of principle for the potential application of silicaNPs as a pharmacological agent to enhance BMD and protect against bone fracture.

TL;DR: The basic design principles of nanoparticle-based CT contrast agents are described and the state-of-the-art developments and clinical applications of blood pool, passive and active targeting CT Contrast Agents are reviewed.

TL;DR: This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications.

TL;DR: This review presents an introduction to polymer nanofiber electrospinning, focusing on the use of natural proteins and synthetic peptides, and describes key properties and applications of these materials, and outline future prospects for tissue engineering, drug delivery, wound healing, and biosensors based on these nanomats and nanofibers.

TL;DR: This review describes various nanoparticle (NP)-based methods used for drug delivery to the brain and the known underlying mechanisms and some strategies require multifunctional NPs combining controlled passage across the BBB with targeted delivery of the therapeutic cargo to the intended site of action in the brain.

TL;DR: It is demonstrated that high negative surface charge and drug effects leading to distortion of liposome sphericity might be the most critical factors leading to CARPA, and the applied tests might be used to predict CARPA in humans.

TL;DR: A review of potential drug delivery systems for CUR including liposomes, polymeric nanoparticles, solid lipid nanoparticles (SLP), micelles, nanogels, nanosuspensions, nanoemulsions, complexes and dendrimer/dimer is presented in this paper.

TL;DR: This review focuses on the diagnostic applications of Raman spectroscopy in the past 5 years, with specific emphasis on transplant allograft rejection and cancer detections.

TL;DR: It is demonstrated that ovarian cells are stiffer and more viscous when they are benign, and the increase in cell deformability directly correlates with the progression of a transformed phenotype from a nontumorigenic, benign cell to a tumorigenics, malignant one.

TL;DR: The effects of size and injection dose on the biodistribution of GO are studied to accelerate the development of a GO-based drug and small-sized GO with suitable funtionalization is recommended for medical applications.

TL;DR: A nanomedical device that profiles volatile organic compounds in lung cancer cells is investigated, using a matrix of gold nanoparticle (GNP) sensors that are suitable for detecting lung cancer (LC) specific patterns of VOC profiles, as determined by gas chromatography-mass spectrometry analysis.

TL;DR: Preliminary results of plasmon-enhanced localized hyperthermia both in vitro and in vivo demonstrate that Au nanostars may be efficient photothermal agents for cancer therapy.

TL;DR: It is demonstrated that gold nanoparticles can be successfully applied to overcome MDR in cancer chemotherapy and efficiently released the anticancer drug DOX and enhanced its cytotoxicity against MDR cancer cells.

TL;DR: The authors report the development of sdAbs-QD-oriented conjugates, comprised of single domain antibodies that are 12 times smaller than regular mAb-s and quantum dots that represent a new generation of ultrasmall diagnostic probes for applications in high-throughput diagnostic platforms.

TL;DR: Recent advances in optical molecular imaging are reviewed, highlighting the advances in technology required to improve early cancer detection, guide selection of targeted therapy and rapidly evaluate therapeutic efficacy.

TL;DR: In this paper, the pharmacokinetics, biodistribution, and antitumor efficacy of three doxorubicin formulations were investigated in Walker 256 tumor-bearing rats.

TL;DR: Overall, this study has developed a patient-compliant, oral nanoformulation of insulin, once-daily administration of which would be sufficient to control diabetes for at least 24 h.