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Pascal Beck
Researcher at Novartis
Publications - 2
Citations - 1386
Pascal Beck is an academic researcher from Novartis. The author has contributed to research in topics: GABAB receptor & Receptor. The author has an hindex of 2, co-authored 2 publications receiving 1361 citations.
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Journal ArticleDOI
Gabab-receptor subtypes assemble into functional heteromeric complexes
Klemens Kaupmann,Barbara Malitschek,Valerie Schuler,Jakob Heid,Wolfgang Froestl,Pascal Beck,Johannes Mosbacher,Serge Bischoff,Ákos Kulik,Ryuichi Shigemoto,Andreas Karschin,Bernhard Bettler +11 more
TL;DR: A new GABAB receptor subtype is described, GABABR2, which does not bind available GABAB antagonists with measurable potency and exhibits a significant increase in agonist- and partial-agonist-binding potencies as compared with individual receptors.
Journal ArticleDOI
γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors
Kurt Lingenhoehl,Richard Brom,Jakob Heid,Pascal Beck,Wolfgang Froestl,Klemens Kaupmann,Bernhard Bettler,Johannes Mosbacher +7 more
TL;DR: Results indicate that GHB is a weak partial agonist at the GABA binding site of GABA(B)R1/R2, and this hypothesis is consistent with previous reports on GHB and gamma-aminobutyric acid.