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Andreas Karschin
Researcher at University of Würzburg
Publications - 98
Citations - 7717
Andreas Karschin is an academic researcher from University of Würzburg. The author has contributed to research in topics: Potassium channel & Receptor. The author has an hindex of 47, co-authored 97 publications receiving 7440 citations. Previous affiliations of Andreas Karschin include Max Planck Society & California Institute of Technology.
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Gabab-receptor subtypes assemble into functional heteromeric complexes
Klemens Kaupmann,Barbara Malitschek,Valerie Schuler,Jakob Heid,Wolfgang Froestl,Pascal Beck,Johannes Mosbacher,Serge Bischoff,Ákos Kulik,Ryuichi Shigemoto,Andreas Karschin,Bernhard Bettler +11 more
TL;DR: A new GABAB receptor subtype is described, GABABR2, which does not bind available GABAB antagonists with measurable potency and exhibits a significant increase in agonist- and partial-agonist-binding potencies as compared with individual receptors.
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International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels
George A. Gutman,K. George Chandy,John P. Adelman,Jayashree Aiyar,Douglas A. Bayliss,David E. Clapham,Manuel Covarriubias,Gary V. Desir,Kiyoshi Furuichi,Barry Ganetzky,Maria L. Garcia,Stephan Grissmer,Lily Yeh Jan,Andreas Karschin,Donghee Kim,Sabina Kuperschmidt,Yoshihisa Kurachi,Michel Lazdunski,Florian Lesage,Henry A. Lester,David McKinnon,Colin G. Nichols,I. T. A. O'kelly,Jonathan Robbins,Gail A. Robertson,Bernardo Rudy,Michael C. Sanguinetti,Susumu Seino,Walter Stuehmer,Michael M. Tamkun,Carol A. Vandenberg,Aguan Wei,Heike Wulff,Randy S. Wymore +33 more
TL;DR: An overview of the molecular relationships among the voltage-gated potassium channels and a standard nomenclature for them is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels as mentioned in this paper.
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IRK(1–3) and GIRK(1–4) Inwardly Rectifying K+Channel mRNAs Are Differentially Expressed in the Adult Rat Brain
TL;DR: The differential mRNA expression and detailed cellular localization in the adult rat brain of seven members of the IRK and GIRK subfamilies is demonstrated and additional functional characterization based on overlapping expression patterns may help to decipher the native K+ channels in neurons and glial cells.
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TASK-3, a novel tandem pore domain acid-sensitive K+ channel.
Sindhu Rajan,Erhard Wischmeyer,Gongxin Liu,Regina Preisig-Müller,Jürgen Daut,Andreas Karschin,Christian Derst +6 more
TL;DR: Exercise of TASK-3 in Xenopus oocytes revealed an outwardly rectifying K+ current that was strongly decreased in the presence of lower extracellular pH, and substitution of the histidine residue His-98 by asparagine or tyrosine abolished pH sensitivity.
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International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels
Yoshihiro Kubo,John P. Adelman,David E. Clapham,Lily Yeh Jan,Andreas Karschin,Yoshihisa Kurachi,Michel Lazdunski,Colin G. Nichols,Susumu Seino,Carol A. Vandenberg +9 more
TL;DR: Since the initial cDNA cloning of the first inward rectifiers Kir1.1 and Kir2.1 in 1993, a succession of new members of this family have been identified, including the G protein-coupled Kir3 and the ATP-sensitive Kir6, which play an important physiological role in the nervous system.