P
Pascale Durbec
Researcher at National Institute for Medical Research
Publications - 5
Citations - 1555
Pascale Durbec is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Enteric nervous system & Receptor tyrosine kinase. The author has an hindex of 5, co-authored 5 publications receiving 1506 citations.
Papers
More filters
Journal ArticleDOI
GDNF signalling through the Ret receptor tyrosine kinase
Pascale Durbec,Camelia V. Marcos-Gutierrez,Carol Kilkenny,Maria Grigoriou,Kirmo Wartiowaara,Petro Suvanto,Darrin P. Smith,Bruce A.J. Ponder,Frank Costantini,Mart Saarma,Hannu Sariola,Vassilis Pachnis +11 more
TL;DR: It is shown that glial-cell-line-derived neurotrophic factor (GDNF)7, a distant member of the transforming growth factor(TGF)-β superfamily, signals through the Ret RTK, and that GDNF, in addition to its potential role in the differentiation and survival of central nervous system neurons8–12, has profound effects on kidney organogenesis and the development of the peripheral nervous system.
Journal ArticleDOI
Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.
TL;DR: In situ hybridization studies, as well as direct labelling of cells with DiI, indicate that a common pool of neural crest cells derived from the postotic hindbrain normally gives rise to most of the enteric nervous system and the superior cervical ganglion, and is uniquely dependent on c-ret function for normal development.
Journal ArticleDOI
Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
Stavros Taraviras,Camelia V. Marcos-Gutierrez,Pascale Durbec,Harsha R. Jani,Maria Grigoriou,Madhu Sukumaran,Li-Chong Wang,Mary Hynes,Geoffrey Raisman,Vassilis Pachnis +9 more
TL;DR: It is suggested that normal function of the RET RTK is required in vivo during early stages of ENS histogenesis for the survival of undifferentiated enteric NC and their derivatives.
Journal ArticleDOI
III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system
TL;DR: A number of assays are developed and briefly described here that analyze the specific function of the RET receptor and its ligand and suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.
Journal Article
Neural Injury, Repair, and Adaptation in the GI Tract III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system
TL;DR: A number of assays are developed and briefly described here that analyze the specific function of the RET receptor and its ligand and suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.