L
Lena Larsson-Blomberg
Researcher at National Institute for Medical Research
Publications - 4
Citations - 2065
Lena Larsson-Blomberg is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Receptor tyrosine kinase & Neural crest. The author has an hindex of 4, co-authored 4 publications receiving 2004 citations. Previous affiliations of Lena Larsson-Blomberg include Medical Research Council.
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Journal ArticleDOI
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
Anita Schuchardt,Vivette D. D'Agati,Lena Larsson-Blomberg,Frank Costantini,Vassilis Pachnis,Vassilis Pachnis +5 more
TL;DR: It is shown that mice homozygous for a targeted mutation in c-ret develop to term, but die soon after birth, showing renal agenesis or severe dysgenesis, and lacking enteric neurons throughout the digestive tract, indicating an essential component of a signalling pathway required for renal organogenesis and enteric neurogenesis.
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Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.
TL;DR: In situ hybridization studies, as well as direct labelling of cells with DiI, indicate that a common pool of neural crest cells derived from the postotic hindbrain normally gives rise to most of the enteric nervous system and the superior cervical ganglion, and is uniquely dependent on c-ret function for normal development.
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RET‐deficient mice: an animal model for Hirschsprung's disease and renal agenesis
TL;DR: A targeted mutation in the murine c‐ret locus shows that the ret receptor is required for normal development of two lineally unrelated systems, the excretory system and the enteric nervous system.
Journal ArticleDOI
Isolation of tyrosine kinase related genes expressed in the early hematopoietic system
TL;DR: The twelve isolated kinases are described, the specific expression patterns of flk‐1, tek and ryk kinases and their potential relationship to the development of the hematopoietic system are described.