P
Pat Whitworth
Researcher at Vanderbilt University
Publications - 118
Citations - 11120
Pat Whitworth is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 33, co-authored 81 publications receiving 9698 citations. Previous affiliations of Pat Whitworth include Duke University.
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Journal ArticleDOI
Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial
Armando E. Giuliano,Kelly K. Hunt,Karla V. Ballman,Peter D. Beitsch,Pat Whitworth,Peter W. Blumencranz,A. Marilyn Leitch,Sukamal Saha,Linda M. McCall,Monica Morrow +9 more
TL;DR: Among patients with limited SLN metastatic breast cancer treated with breast conservation and systemic therapy, the use of SLND alone compared with ALND did not result in inferior survival, and overall survival was the primary end point, with a noninferiority margin of a 1-sided hazard ratio of less than 1.3 indicating thatSLND alone is noninherited.
Journal ArticleDOI
The sentinel node in breast cancer--a multicenter validation study.
David N. Krag,Donald L. Weaver,Takamaru Ashikaga,Frederick L. Moffat,V. Suzanne Klimberg,Craig D. Shriver,Sheldon Feldman,Roberto Kusminsky,Michele A. Gadd,Joseph A. Kuhn,Seth P. Harlow,Peter D. Beitsch,Pat Whitworth,Roger S. Foster,Kambiz Dowlatshahi +14 more
TL;DR: Biopsy of sentinel nodes can predict the presence or absence of axillary-node metastases in patients with breast cancer, however, the procedure can be technically challenging, and the success rate varies according to the surgeon and the characteristics of the patient.
Journal ArticleDOI
Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial.
Armando E. Giuliano,Linda M. McCall,Peter D. Beitsch,Pat Whitworth,Peter W. Blumencranz,A. Marilyn Leitch,Sukamal Saha,Kelly K. Hunt,Monica Morrow,Karla V. Ballman +9 more
TL;DR: Despite the potential for residual axillary disease after SLND, SLND without ALND can offer excellent regional control and may be reasonable management for selected patients with early-stage breast cancer treated with breast-conserving therapy and adjuvant systemic therapy.
Journal ArticleDOI
Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial
Armando E. Giuliano,Karla V. Ballman,Linda M. McCall,Peter D. Beitsch,Meghan Brennan,Pond R. Kelemen,David W. Ollila,Nora M. Hansen,Pat Whitworth,Peter W. Blumencranz,A. Marilyn Leitch,Sukamal Saha,Kelly K. Hunt,Monica Morrow +13 more
TL;DR: Findings do not support routine use of axillary lymph node dissection in this patient population based on 10-year outcomes, and overall survival for patients treated with sentinel lymph nodes dissection alone was noninferior toOverall survival for those treated with axillary node dissections.
Journal ArticleDOI
Surgical Complications Associated With Sentinel Lymph Node Biopsy: Results From a Prospective International Cooperative Group Trial
Lee G. Wilke,Linda M. McCall,Katherine E. Posther,Pat Whitworth,Douglas S. Reintgen,A. Marilyn Leitch,Sheryl G. A. Gabram,Anthony Lucci,Charles E. Cox,Kelly K. Hunt,James E. Herndon,Armando E. Giuliano +11 more
TL;DR: This study provides a prospective assessment of the sentinel lymph node biopsy procedure, as performed by a wide range of surgeons, demonstrating a low complication rate.