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Anushka C. Galasiti Kankanamalage
Researcher at Wichita State University
Publications - 19
Citations - 780
Anushka C. Galasiti Kankanamalage is an academic researcher from Wichita State University. The author has contributed to research in topics: Protease & Coronavirus. The author has an hindex of 12, co-authored 18 publications receiving 604 citations. Previous affiliations of Anushka C. Galasiti Kankanamalage include Scripps Research Institute.
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Journal ArticleDOI
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
Yunjeong Kim,Hongwei Liu,Anushka C. Galasiti Kankanamalage,Sahani Weerasekara,Duy H. Hua,William C. Groutas,Kyeong-Ok Chang,Niels C Pedersen +7 more
TL;DR: It is found that antiviral treatment led to full recovery of cats when treatment was started at a stage of disease that would be otherwise fatal if left untreated, and results indicate that continuous virus replication is required for progression of immune-mediated inflammatory disease of FIP.
Journal ArticleDOI
Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis.
Niels C Pedersen,Yunjeong Kim,Hongwei Liu,Anushka C. Galasiti Kankanamalage,Chrissy Eckstrand,William C. Groutas,Michael J. Bannasch,Juliana M. Meadows,Kyeong-Ok Chang +8 more
TL;DR: GC376 showed promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.
Journal ArticleDOI
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Anushka C. Galasiti Kankanamalage,Yunjeong Kim,Vishnu C. Damalanka,A.D. Rathnayake,Anthony R. Fehr,N. Mehzabeen,Kevin P. Battaile,Scott Lovell,Gerald H. Lushington,Stanley Perlman,Kyeong-Ok Chang,William C. Groutas +11 more
TL;DR: The structure-guided design and evaluation of a novel class of inhibitors of MERS-CoV 3CL protease that embody a piperidine moiety as a design element that is well-suited to exploiting favorable subsite binding interactions to attain optimal pharmacological activity and PK properties are described.
Journal ArticleDOI
Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses
Yunjeong Kim,Vinay Shivanna,Sanjeev Narayanan,Allan M. Prior,Sahani Weerasekara,Duy H. Hua,Anushka C. Galasiti Kankanamalage,William C. Groutas,Kyeong-Ok Chang +8 more
TL;DR: The results suggest that the series of 3CLpro inhibitors described here may have the potential to be further developed as therapeutic agents against these important viruses in domestic and wild cats and provide the first insight into a structural platform for anti-FIPV and anti-FCV drug development.
Journal ArticleDOI
Structure-Guided Design and Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease. Structure-Activity Relationships and Biochemical, X-ray Crystallographic, Cell-Based, and In Vivo Studies.
Anushka C. Galasiti Kankanamalage,Yunjeong Kim,Pathum M. Weerawarna,Roxanne Adeline Z. Uy,Vishnu C. Damalanka,Sivakoteswara Rao Mandadapu,Kevin R. Alliston,N. Mehzabeen,Kevin P. Battaile,Scott Lovell,Kyeong-Ok Chang,William C. Groutas +11 more
TL;DR: The optimization of dipeptidyl inhibitors of norovirus 3C-like protease is described using iterative SAR, X-ray crystallographic, and enzyme and cell-based studies and in vivo efficacy of an inhibitor is demonstrated using the murine model of Norovirus infection.