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Patricia A. Thompson
Researcher at University of Texas Southwestern Medical Center
Publications - 20
Citations - 1985
Patricia A. Thompson is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Monocyte & Lipoprotein. The author has an hindex of 19, co-authored 20 publications receiving 1929 citations. Previous affiliations of Patricia A. Thompson include University of Texas at Dallas & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region.
Alexander Poltorak,Irina Smirnova,Xiaolong He,Mu Ya Liu,Christophe Van Huffel,Dale Birdwell,E. Alejos,M. Silva,Xin Du,Patricia A. Thompson,Edward K. L. Chan,Jessica Ledesma,Bruce A. Roe,Sandra W. Clifton,Stefanie N. Vogel,Bruce Beutler +15 more
TL;DR: To identify gene candidates, nearly 40,000 sequencing runs were performed across the critical region, and Selective hybridization and exon trapping were also employed to identify genes throughout the "zero" region.
Journal ArticleDOI
Modulatory effects of sCD14 and LBP on LPS-host cell interactions:
TL;DR: The dual stimulatory and inhibitory mechanisms of sCD14 and LBP may benefit the infected host by promoting inflammation in local sites, where it is needed, while at the same time preventing potentially detrimental systemic responses to LPS.
Journal ArticleDOI
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway
TL;DR: The ras/raf-1/MEK/MAPK pathway is chiefly responsible for transduction of the LPS signal to the level of the TNF gene and mRNA and lies upstream from (or actually represent) the physical branchpoints of the transcriptional and translation activation signals generated by LPS.
Journal ArticleDOI
Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins
Richard L. Kitchens,Patricia A. Thompson,Suganya Viriyakosol,Grant E. O'Keefe,Robert S. Munford +4 more
TL;DR: It is shown that in human serum, sCD14 increases the rate at which cell-bound LPS is released from the monocyte surface and binds to plasma lipoproteins, which diminishes monocyte responses to LPS by transferring cell- bound LPS to lipoproteinins.
Journal Article
Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.
Justin D. Radolf,Michael V. Norgard,Mary E. Brandt,Robin D. Isaacs,Patricia A. Thompson,Patricia A. Thompson,Bruce Beutler +6 more
TL;DR: Through their ability to induce TNF production by macrophages, spirochete lipoproteins may play important roles in the development of the local inflammatory changes and the systemic manifestations that characterize syphilis and Lyme disease.