Patricia C. Cogswell

TL;DR: It is shown that the synthetic glucocorticoid dexamethasone induces the transcription of the IκBα gene, which results in an increased rate of Iκbα protein synthesis, which is predicted to markedly decrease cytokine secretion and thus effectively block the activation of the immune system.

TL;DR: Using a sensitive transfection-tumorigenicity assay, a novel transforming gene from the DNA of two patients with chronic myelogenous leukemia is isolated and sequence analysis indicates that the product of this gene, axl, is a receptor tyrosine kinase.

TL;DR: The results provide an explanation for the requirement of NF-kappaB for Ras-mediated oncogenesis and provide evidence that Ras-transformed cells are susceptible to apoptosis even if they do not express the p53 tumor-suppressor gene product.

TL;DR: It is shown here that mTOR downstream from Akt controls NFB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK, and the mTOR-associated protein Raptor is required for the ability of Akt to induce N FB activity.

TL;DR: These studies demonstrate that NF-kappa B augments gene expression mediated by a multimerized c-fos serum response element in the presence of C/EBP.