P
Patricia L. Fernández
Researcher at Federal University of Rio de Janeiro
Publications - 35
Citations - 1975
Patricia L. Fernández is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Heme & Proinflammatory cytokine. The author has an hindex of 13, co-authored 34 publications receiving 1641 citations.
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Journal ArticleDOI
Characterization of heme as activator of Toll-like receptor 4.
Rodrigo T. Figueiredo,Patricia L. Fernández,Diego Mourão-Sá,Bárbara N. Porto,Fabianno F. Dutra,Letícia S. Alves,Marcus F. Oliveira,Pedro L. Oliveira,Aurélio V. Graça-Souza,Marcelo T. Bozza +9 more
TL;DR: It is demonstrated that heme, but not its analogs/precursors, induced tumor necrosis factor-α (TNF-α) secretion by macrophages dependently on MyD88, TLR4, and CD14, and these findings support the concept that the broad ligand specificity ofTLR4 and the different activation profiles might in part reside in its ability to recognize different ligands in different binding sites.
Journal ArticleDOI
Hemolysis-induced lethality involves inflammasome activation by heme
Fabianno F. Dutra,Letícia S. Alves,Danielle A. S. Rodrigues,Patricia L. Fernández,Rosane B. de Oliveira,Douglas T. Golenbock,Dario S. Zamboni,Marcelo T. Bozza +7 more
TL;DR: It is shown that heme induces IL-1β processing through the activation of the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome in macrophages, suggesting that among NLRP3 activators, heme has common as well as unique requirements to trigger inflammaome activation.
Journal ArticleDOI
Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis.
TL;DR: The role of several receptors expressed on microglia in Aβ recognition, uptake, and signaling, and their implications for AD pathogenesis are discussed.
Journal ArticleDOI
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
Guilherme B. Fortes,Letícia S. Alves,Rosane B. de Oliveira,Rosane B. de Oliveira,Fabianno F. Dutra,Danielle A. S. Rodrigues,Patricia L. Fernández,Thaïs Souto-Padrón,Maria Jose de Rosa,Michelle A. Kelliher,Douglas T. Golenbock,Francis Ka-Ming Chan,Marcelo T. Bozza +12 more
TL;DR: It is shown that heme caused early macrophage death characterized by the loss of plasma membrane integrity and morphologic features resembling necrosis, and 2 synergistic mechanisms were revealed: TLR4/Myd88-dependent expression of TNF andTLR4-independent generation of ROS.
Journal ArticleDOI
Heme Induces Neutrophil Migration and Reactive Oxygen Species Generation through Signaling Pathways Characteristic of Chemotactic Receptors
Bárbara N. Porto,Letiícia S. Alves,Patricia L. Fernández,Tatiana P. Dutra,Rodrigo T. Figueiredo,Aurélio V. Graça-Souza,Marcelo T. Bozza +6 more
TL;DR: The results indicate that heme activates neutrophils through signaling pathways that are characteristic of chemoattractant molecules and suggest that mesoporphyrins might prove valuable in the treatment of the inflammatory consequences of hemorrhagic and hemolytic disorders.