Rodrigo T. Figueiredo

TL;DR: It is demonstrated that heme, but not its analogs/precursors, induced tumor necrosis factor-α (TNF-α) secretion by macrophages dependently on MyD88, TLR4, and CD14, and these findings support the concept that the broad ligand specificity ofTLR4 and the different activation profiles might in part reside in its ability to recognize different ligands in different binding sites.

TL;DR: The results indicate that heme activates neutrophils through signaling pathways that are characteristic of chemoattractant molecules and suggest that mesoporphyrins might prove valuable in the treatment of the inflammatory consequences of hemorrhagic and hemolytic disorders.

TL;DR: The results indicate that oxidative stress contributes to parasite persistence in host tissues and open a new avenue for the development of anti-T.

TL;DR: In this article, the authors describe the isolation and structural characterization of an α-glucan from Pseudallescheria boydii cell wall and evaluate its role in the induction of innate immune response.

TL;DR: In vitro, it is demonstrated that A fumigatus induces the release of EETs through a mechanism independent of reactive oxygen species but associated with eosinophil death, histone citrullination, CD11b, and the Syk tyrosine kinase pathway.