M
Marcelo T. Bozza
Researcher at Federal University of Rio de Janeiro
Publications - 135
Citations - 9265
Marcelo T. Bozza is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Macrophage migration inhibitory factor & Heme. The author has an hindex of 47, co-authored 129 publications receiving 8080 citations. Previous affiliations of Marcelo T. Bozza include Oswaldo Cruz Foundation & Harvard University.
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Journal ArticleDOI
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
Fernando A. Bozza,Fernando A. Bozza,Jorge I. F. Salluh,André M. Japiassú,André M. Japiassú,Marcio Soares,Edson F. Assis,Rachel N. Gomes,Marcelo T. Bozza,Hugo C. Castro-Faria-Neto,Patrícia T. Bozza +10 more
TL;DR: In this article, the authors used a multiplex system for simultaneous detection of 17 cytokines (IL-1β, IL-2, IL 4, IL 5, IL 6, IL 7, IL 8, IL 9, IL 10, IL 11, IL 12, IL 13, interferon-γ, MCP-1, macrophage inflammatory protein-1 and tumour necrosis factor-α).
Journal ArticleDOI
Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis.
Marcelo T. Bozza,Abhay R. Satoskar,Guosheng Lin,Bao Lu,Alison A. Humbles,Craig Gerard,John R. David +6 more
TL;DR: The findings of enhanced resistance to P. aeruginosa and resistance to endotoxin-induced lethal shock suggest that the counteraction or neutralization of MIF may serve as an adjunct therapy in sepsis.
Journal ArticleDOI
Characterization of heme as activator of Toll-like receptor 4.
Rodrigo T. Figueiredo,Patricia L. Fernández,Diego Mourão-Sá,Bárbara N. Porto,Fabianno F. Dutra,Letícia S. Alves,Marcus F. Oliveira,Pedro L. Oliveira,Aurélio V. Graça-Souza,Marcelo T. Bozza +9 more
TL;DR: It is demonstrated that heme, but not its analogs/precursors, induced tumor necrosis factor-α (TNF-α) secretion by macrophages dependently on MyD88, TLR4, and CD14, and these findings support the concept that the broad ligand specificity ofTLR4 and the different activation profiles might in part reside in its ability to recognize different ligands in different binding sites.
Journal ArticleDOI
Are reactive oxygen species always detrimental to pathogens
TL;DR: This study reviews the classic infections that are controlled by ROS and the cases in which ROS appear as promoters of infection, challenging the paradigm, and discusses the possible mechanisms by which ROS could promote particular infections.
Journal ArticleDOI
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.
Djalma S. Lima-Junior,Diego L. Costa,Vanessa Carregaro,Larissa D. Cunha,Alexandre L. N. Silva,Tiago W. P. Mineo,Tiago W. P. Mineo,Fredy R. S. Gutierrez,Fredy R. S. Gutierrez,Maria Bellio,Karina R. Bortoluci,Richard A. Flavell,Marcelo T. Bozza,João Santana da Silva,Dario S. Zamboni +14 more
TL;DR: It is shown that the Nlrp3 inflammasome is activated in response to Leishmania infection and is important for the restriction of parasite replication both in macrophages and in vivo as demonstrated through the infection of inflammaome-deficient mice with Leishmaniasis.