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Patricia L. Foster
Researcher at Indiana University
Publications - 101
Citations - 8396
Patricia L. Foster is an academic researcher from Indiana University. The author has contributed to research in topics: Adaptive mutation & Mutation rate. The author has an hindex of 45, co-authored 101 publications receiving 7737 citations. Previous affiliations of Patricia L. Foster include University of Cambridge & Food and Drug Administration.
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Journal ArticleDOI
Genetic drift, selection and the evolution of the mutation rate
Michael Lynch,Matthew S. Ackerman,Jean-François Gout,Hongan Long,Way Sung,W. Kelley Thomas,Patricia L. Foster +6 more
TL;DR: This work concludes that the drift-barrier hypothesis is consistent with comparative measures of mutation rates, provides a simple explanation for the existence of error-prone polymerases and yields a formal counter-argument to the view that selection fine-tunes gene-specific mutation rates.
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Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing
TL;DR: Comparing results from the wild-type and MMR-defective strains may lead to a deeper understanding of factors that determine mutation rates and spectra, how these factors may differ among organisms, and how they may be shaped by environmental conditions.
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Adaptive Reversion of a Frameshift Mutation in Escherichia coli
John Cairns,Patricia L. Foster +1 more
TL;DR: A strain of Escherichia coli which constitutively expresses a lacI-lacZ fusion containing a frameshift mutation that renders it Lac+, a rare event during exponential growth but occurs in stationary cultures when lactose is the only source of energy.
Journal ArticleDOI
Determining Mutation Rates in Bacterial Populations
TL;DR: A number of methods to estimate mutation rates are described, brief accounts of their derivations are given, and how they behave under various experimental conditions are discussed.
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Stress-induced mutagenesis in bacteria.
TL;DR: Bacteria spend their lives buffeted by changing environmental conditions and under a variety of stressful conditions, bacteria are induced for genetic change and this transient mutator state may be important for adaptive evolution.