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Patrick Augustijns
Researcher at Katholieke Universiteit Leuven
Publications - 358
Citations - 16730
Patrick Augustijns is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Intestinal absorption & Medicine. The author has an hindex of 65, co-authored 333 publications receiving 13798 citations. Previous affiliations of Patrick Augustijns include Purdue University.
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Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?
TL;DR: Methods and excipients associated with the development of supersaturating drug delivery systems are assessed and the future directions and factors likely to contribute to or detract from optimal dosage form selection are assessed.
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Top-Down Production of Drug Nanocrystals - Nanosuspension Stabilization, Miniaturization and Transformation Into Solid Products
TL;DR: This mini-review focuses on recent advances with respect to three topics considering drug nanocrystals, focussing on the maintenance of the preservation of the rapid dissolution properties of the nanocry crystals after further downstream processing.
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In vitro models for the prediction of in vivo performance of oral dosage forms
Edmund Kostewicz,Bertil Abrahamsson,Marcus E. Brewster,Joachim Brouwers,James Butler,Sara Carlert,Paul A. Dickinson,Jennifer B. Dressman,René Holm,Sandra Klein,James Mann,Mark McAllister,Mans Minekus,Uwe Muenster,Anette Müllertz,Miriam Verwei,Maria Vertzoni,Werner Weitschies,Patrick Augustijns +18 more
TL;DR: It is anticipated that the innovative in vitro biopharmaceutical tools arising from the OrBiTo project will lead to improved predictions for in vivo behavior of drug formulations in the GI tract.
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Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs
Michiel Van Speybroeck,Valéry Barillaro,Thao Do Thi,Randy Mellaerts,Johan A. Martens,Jan Van Humbeeck,Jan Vermant,Pieter Annaert,Guy Van den Mooter,Patrick Augustijns +9 more
TL;DR: The results of this study suggest that encapsulation in SBA-15 can be applied as a dissolution-enhancing formulation approach for a very wide variety of poorly soluble drugs.
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In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
Erik Sjögren,Bertil Abrahamsson,Patrick Augustijns,Dieter Becker,Michael B. Bolger,Marcus E. Brewster,Joachim Brouwers,Talia Flanagan,Matthew D Harwood,Christian Heinen,René Holm,Hans-Paul Juretschke,Marlies Kubbinga,Anders Lindahl,Viera Lukacova,Uwe Münster,Sibylle Neuhoff,Mai Anh Nguyen,Achiel Van Peer,Christos Reppas,Amin Rostami Hodjegan,Christer Tannergren,Werner Weitschies,Clive G. Wilson,P. Zane,Hans Lennernäs,Peter Langguth +26 more
TL;DR: This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals with emphasis on in vivo methods for testing and prediction of oral dosage form performance.