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Patrick B. Kyle
Researcher at University of Mississippi Medical Center
Publications - 45
Citations - 840
Patrick B. Kyle is an academic researcher from University of Mississippi Medical Center. The author has contributed to research in topics: Kidney & HELLP syndrome. The author has an hindex of 15, co-authored 42 publications receiving 683 citations. Previous affiliations of Patrick B. Kyle include University of Mississippi.
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Journal ArticleDOI
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.
Anteneh M. Feyissa,William L. Woolverton,Jose Javier Miguel-Hidalgo,Zhixia Wang,Patrick B. Kyle,Gregor Hasler,Craig A. Stockmeier,Craig A. Stockmeier,Abiye H. Iyo,Beata Karolewicz +9 more
TL;DR: These findings provide the first evidence that mGluR2/3 is elevated in the PFC in MDD and demonstrates that these receptors are promising targets for the discovery of novel antidepressants.
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Oligodendrocyte morphometry and expression of myelin – Related mRNA in ventral prefrontal white matter in major depressive disorder
Grazyna Rajkowska,Gouri Mahajan,Dorota Maciag,Monica Sathyanesan,Abiye H. Iyo,Mohadetheh Moulana,Patrick B. Kyle,William L. Woolverton,Jose Javier Miguel-Hidalgo,Craig A. Stockmeier,Samuel S. Newton +10 more
TL;DR: Altered expression of four myelin genes and CNPase protein suggests a mechanism for the degeneration of cortical axons and dysfunctional maturation of oligodendrocytes in MDD.
Journal ArticleDOI
Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
Samuel O. Adeosun,Xu Hou,Yun Jiao,Baoying Zheng,Sherry Henry,Rosanne L.L. Hill,Zhi He,Amar K. Pani,Patrick B. Kyle,Xiao-Ming Ou,Thomas H. Mosley,Jerry M. Farley,Craig A. Stockmeier,Ian A. Paul,Steven A. Bigler,Roberta Diaz Brinton,Richard J. Smeyne,Jun Ming Wang +17 more
TL;DR: It is demonstrated that allopregnanolone promotes the restoration of tyrosine hydroxylase immunoreactive neurons and total cells in the nigrostriatal tract, improves the motor performance in MPTP-treated mice, and may serve as a therapeutic strategy for Parkinson's disease.
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Severe illness associated with reported use of synthetic cannabinoids - Mississippi, April 2015
Amelia M. Kasper,Alison Ridpath,Justin K. Arnold,Kevin Chatham-Stephens,Melissa Morrison,Olaniyi Olayinka,Christina Parker,Robert L. Galli,Robert D. Cox,Nykiconia Preacely,Jannifer Anderson,Patrick B. Kyle,Roy Gerona,Colleen Martin,Josh Schier,Amy Wolkin,Thomas Dobbs +16 more
TL;DR: The Mississippi State Department of Health and CDC initiated an investigation to better characterize the outbreak, identify risk factors associated with severe illness, and prevent additional illnesses and deaths.
Journal ArticleDOI
AACC Guidance Document on Biotin Interference in Laboratory Tests.
TL;DR: The recent increase in the use of high-dose biotin supplements requires laboratorians and clinicians to be mindful of the potential for biotin interference in biotinylated immunoassay-based laboratory tests.