Richard J. Smeyne

TL;DR: These findings demonstrate that Trk is the primary mediator of the trophic actions of NGF in vivo and that this signalling pathway plays a crucial role in the development of both the peripheral and the central nervous systems.

TL;DR: Evidence is provided showing that the continuous expression of Fos, beginning hours or days before the morphological demise of the cell, appears to be a hallmark of terminal differentiation and a harbinger of death.

TL;DR: Neuroanatomical examination of trkBTK (-/-) mice revealed neuronal deficiencies in the central and peripheral nervous systems, illustrating the role of the gp145trkB protein-tyrosine kinase receptor in the ontogeny of the mammalian nervous system.

TL;DR: It is shown that homozygous mice defective for TrkC tyrosine protein kinase receptors lack la muscle afferent projections to spinal motor neurons and have fewer large myelinated axons in the dorsal root and posterior columns of the spinal cord, indicating that NT3/TrkC-dependent sensory neurons may play a primary role in proprioception, the sense of position and movement of the limbs.

TL;DR: Stark results indicate that Nrf2 expression restricted to astrocytes is sufficient to protect against MPTP andAstrocytic modulation of the NRF2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing neuronal death in PD.