P
Patrick Garidel
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 103
Citations - 4019
Patrick Garidel is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Isothermal titration calorimetry & Lipid A. The author has an hindex of 39, co-authored 88 publications receiving 3631 citations. Previous affiliations of Patrick Garidel include Kaiserslautern University of Technology.
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Journal ArticleDOI
Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation.
Lauren Mashburn-Warren,Jörg Howe,Patrick Garidel,Walter Richter,Frank Steiniger,Manfred Roessle,Klaus Brandenburg,Marvin Whiteley +7 more
TL;DR: Insight is provided into the molecular mechanism of P. aeruginosa MV formation and it is demonstrated that quorum signals serve important non‐signalling functions.
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Thermodynamic Characterization of Bile Salt Aggregation as a Function of Temperature and Ionic Strength Using Isothermal Titration Calorimetry
TL;DR: In this article, the critical micellar concentration and the demicellization enthalpy ΔHdemic of the primary aggregates of NaC and NaDC in water and 0.1 M NaCl at pH 7.5 were determined by isothermal titration calorimetry.
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The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids
Marcela Manrique Moreno,Marcela Manrique Moreno,Patrick Garidel,Mario Suwalsky,Jörg Howe,Klaus Brandenburg +5 more
TL;DR: Despite the strong influence of the drugs on the acyl chain moiety, FRET data do not reveal any evidence for drug incorporation into the lipid matrix, and ITC measurements performed do not exhibit any heat production due to drug binding, implying that the interaction process is governed by only entropic reactions at the lipid/water interface.
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Composition dependence of vesicle morphology and mixing properties in a bacterial model membrane system
B. Pozo Navas,Karl Lohner,Günter Deutsch,Eva Sevcsik,Karin A. Riske,Rumiana Dimova,Patrick Garidel,Georg Pabst +7 more
TL;DR: The existence of a region of immiscibility is a general feature of PE/PG mixtures and the mixing properties are dominated by PE/ PG headgroup interactions, but are largely independent of the composition of the hydrocarbon chains.
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Membranolytic activity of bile salts: influence of biological membrane properties and composition.
TL;DR: The two main steps of the membranolytic activity of detergents: the partitioning of detergent molecules in the membrane and the solubilisation of the membrane are systematically investigated.