P
Patrick Gilon
Researcher at Université catholique de Louvain
Publications - 106
Citations - 7795
Patrick Gilon is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Insulin & Tolbutamide. The author has an hindex of 47, co-authored 101 publications receiving 7162 citations. Previous affiliations of Patrick Gilon include Catholic University of Leuven.
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Journal ArticleDOI
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function
TL;DR: The mechanisms explaining the glucose dependence of the effects of ACh on insulin release are discussed, which involves a marked, PKC-mediated increase in the efficiency of Ca(2+) on exocytosis of insulin granules.
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Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells.
TL;DR: There exists a mechanism by which glucose can control insulin release independently from changes in K(+)-ATP channel activity, in membrane potential, and in cytosolic Ca2+, which may serve to amplify the secretory response to the triggering signal.
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Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
TL;DR: In this article, the effects of glucocorticoids on pancreatic beta cell function were studied with normal mouse islets and it was shown that dexamethasone treatment significantly inhibited insulin secretion.
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Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.
TL;DR: This study is the first direct demonstration that, in an intact organ, sustained oscillations of Ca2+i induced by a physiological stimulus entrain synchronous oscillation of the functional response, and that both events can vary simultaneously or be dissociated depending on the experimental conditions.
Journal ArticleDOI
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.
Katleen Lemaire,Magalie A. Ravier,Anica Schraenen,John W.M. Creemers,R Van de Plas,Mikaela Granvik,L. Van Lommel,Etienne Waelkens,Fabrice Chimienti,Guy A. Rutter,Patrick Gilon,P. In't Veld,Frans Schuit +12 more
TL;DR: The data show that the ZnT8 transporter is essential for the formation of insulin crystals in beta cells, contributing to the packaging efficiency of stored insulin.