G
Guy A. Rutter
Researcher at Imperial College London
Publications - 451
Citations - 25901
Guy A. Rutter is an academic researcher from Imperial College London. The author has contributed to research in topics: Insulin & Glucose homeostasis. The author has an hindex of 83, co-authored 410 publications receiving 22654 citations. Previous affiliations of Guy A. Rutter include University of Bristol & Hammersmith Hospital.
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Journal ArticleDOI
Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming
TL;DR: A direct role of mitochondrial Ca(2+) in driving ATP production is demonstrated and a form of cellular memory is unraveled that allows a prolonged metabolic activation in stimulated cells.
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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
Daniel Andrade Da Cunha,Paul Hekerman,Laurence Ladrière,Angie Bazarra-Castro,Fernanda Ortis,Marion C. Wakeham,Fabrice Moore,Joanne Rasschaert,Alessandra K Cardozo,Elisa A. Bellomo,Lutgart Overbergh,Chantal Mathieu,Roberto Lupi,Tsonwin Hai,André Herchuelz,Piero Marchetti,Guy A. Rutter,Decio L. Eizirik,Miriam Cnop,Miriam Cnop +19 more
TL;DR: Saturated FFA induce ER stress via ER Ca2+ depletion and the IRE1 and resulting JNK activation contribute to β-cell apoptosis, suggesting that ER stress in primary β-cells is primarily lipotoxic, and not glucolipotoxic.
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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis.
Jan L. Vinkenborg,Tamara J. Nicolson,Elisa A. Bellomo,Melissa S. T. Koay,Guy A. Rutter,Maarten Merkx +5 more
TL;DR: Genetically encoded fluorescence resonance energy transfer (FRET)-based sensors that display a large ratiometric change upon Zn2+ binding, have affinities that span the pico- to nanomolar range and can readily be targeted to subcellular organelles are developed.
Journal ArticleDOI
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.
Philipp A. Gerber,Guy A. Rutter +1 more
TL;DR: Better understanding of the role of oxidative changes, its modulation by genes involved in disease risk, and effects on beta-cell identity may facilitate the development of new therapeutic strategies to this disease.
Journal ArticleDOI
Integrating cytosolic calcium signals into mitochondrial metabolic responses
Lawrence D. Robb-Gaspers,Paul Burnett,Guy A. Rutter,Richard M. Denton,Rosario Rizzuto,Andrew P. Thomas +5 more
TL;DR: In this article, the authors showed that vasopressin-induced [Ca2+]m spike evoked a transient increase in NAD(P)H that persisted longer than the [Ca 2]m increase, which could be related to changes in the activity state of pyruvate dehydrogenase (PDH).