Patrick M. Forgione

TL;DR: Weight loss has dichotomous effects on airway physiology and T-cell function typically involved in the pathogenesis of asthma, suggesting that obesity produces a unique phenotype of asthma that will require a distinct therapeutic approach.

TL;DR: Obesity is associated with increased markers of inflammation in serum and adipose tissue, and yet decreased airway inflammation in obese people with asthma; these patterns reverse with bariatric surgery.

TL;DR: The aim of the present study was to determine in the two phenotypes of obese asthma the effect of weight loss on small airway function.

TL;DR: The travel distance to the clinic did not seem to be a significant predictor of compliance in a cohort of LAGB patients with ≤ 1 year of follow-up in a rural setting, however, a weak relationship was found between the travel distanceto the clinic and weight loss, with patients who traveled further seeming to lose slightly more weight.

TL;DR: It is reported that the methacholine hyperresponsiveness in these models of inherent obese asthma and obese allergic asthma manifests in distinct anatomical compartments but that both are amenable to interventions that induce substantial weight loss.