Open AccessDOI
Surgical advances in the management of brain metastases.
Patrick R Ng,Bryan D. Choi,Manish K. Aghi,Brian V. Nahed +3 more
- Vol. 3
TLDR
For example, in this paper, the authors proposed keyhole craniotomies and tubular retractors to optimize the preservation of normal parenchyma without compromising the extent of resection.Abstract:
As the epidemiological and clinical burden of brain metastases continues to grow, advances in neurosurgical care are imperative. From standard magnetic resonance imaging (MRI) sequences to functional neuroimaging, preoperative workups for metastatic disease allow high-resolution detection of lesions and at-risk structures, facilitating safe and effective surgical planning. Minimally invasive neurosurgical approaches, including keyhole craniotomies and tubular retractors, optimize the preservation of normal parenchyma without compromising extent of resection. Supramarginal surgery has pushed the boundaries of achieving complete removal of metastases without recurrence, especially in eloquent regions when paired with intraoperative neuromonitoring. Brachytherapy has highlighted the potential of locally delivering therapeutic agents to the resection cavity with high rates of local control. Neuronavigation has become a cornerstone of operative workflow, while intraoperative ultrasound (iUS) and intraoperative brain mapping generate real-time renderings of the brain unaffected by brain shift. Endoscopes, exoscopes, and fluorescent-guided surgery enable increasingly high-definition visualizations of metastatic lesions that were previously difficult to achieve. Pushed forward by these multidisciplinary innovations, neurosurgery has never been a safer, more effective treatment for patients with brain metastases.read more
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Journal ArticleDOI
Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma
Charlton Tsai,Bastien Nguyen,Anisha Luthra,Joanne F. Chou,Lara Feder,Laura H. Tang,Vivian E. Strong,Daniela Molena,David R. Jones,Daniel G. Coit,David H. Ilson,Geoffrey Y. Ku,Darren Cowzer,John Cadley,Marinela Capanu,Nikolaus Schultz,Kathryn Beal,Nelson S Moss,Yelena Y. Janjigian,Steven Brad Maron +19 more
TL;DR: These findings suggest that modern treatment approaches are associated with improved prognosis for patients with brain metastasis from gastroesophageal adenocarcinoma.
Journal ArticleDOI
Revisiting the Role of Surgical Resection for Brain Metastasis
Joo Won Byun,Jong-Hyun Kim +1 more
TL;DR: In this paper , the authors discuss the evolving role of surgery in patients with brain metastasis and the future of BM treatment and the role of surgical resection in brain tumor management.
References
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