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Steven Dooley
Researcher at Heidelberg University
Publications - 235
Citations - 11766
Steven Dooley is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hepatic stellate cell & Transforming growth factor. The author has an hindex of 53, co-authored 203 publications receiving 9822 citations.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Roles of TGF-beta in hepatic fibrosis.
TL;DR: The ubiquitous pathophysiologic relevance of TGF-beta suggests its measurement in blood as a diagnostic tool and the importance of cross-talk among different signaling pathways to either specify, enhance, or inhibit T GF-beta responses.
Journal ArticleDOI
TGF-β in progression of liver disease
Steven Dooley,Peter ten Dijke +1 more
TL;DR: The cell-type-directed double-edged role of TGF-β in various liver disease stages is summarised and it is emphasised that, in order to achieve therapeutic effects, it needs to target T GF-β signalling in the right cell type at the right time.
Journal ArticleDOI
TGF-β signalling and liver disease.
Isabel Fabregat,Joaquim Moreno-Càceres,Aránzazu Sánchez,Steven Dooley,Bedair Dewidar,Bedair Dewidar,Gianluigi Giannelli,Peter ten Dijke +7 more
TL;DR: Light is shed on the state‐of‐the‐art in the signalling pathways induced by TGF‐β that are involved in different stages of liver physiology and pathology that are being explored to counteract liver disease progression.
Journal ArticleDOI
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis-Updated 2019.
TL;DR: Impact of TGF-β on liver fibrogenesis related biological processes, such as senescence, metabolism, reactive oxygen species generation, epigenetics, circadian rhythm, epithelial mesenchymal transition, and endothelial-mesenchyal transition are described.