P
Patrik Engström
Researcher at University of California, Berkeley
Publications - 25
Citations - 439
Patrik Engström is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Chlamydia trachomatis & Innate immune system. The author has an hindex of 10, co-authored 25 publications receiving 296 citations. Previous affiliations of Patrik Engström include Umeå University.
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Journal ArticleDOI
Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence
Patrik Engström,Thomas P. Burke,Gabriel Mitchell,Nadia Ingabire,Nadia Ingabire,Kevin G. Mark,Guillaume Golovkine,Anthony T. Iavarone,Michael Rape,Jeffery S. Cox,Matthew D. Welch +10 more
TL;DR: It is shown that actin mobilization is insufficient to block autophagy recognition of the pathogen Rickettsia parkeri, and outer membrane protein B (OmpB) is employed to block ubiquitylation of the bacterial surface proteins, thereby evading destruction by host autophagic processes.
Journal ArticleDOI
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis.
Thomas P. Burke,Patrik Engström,Roberto A. Chavez,Joshua A. Fonbuena,Joshua A. Fonbuena,Russell E. Vance,Matthew D. Welch +6 more
TL;DR: Rickettsia parkeri is shown to be sensitive to type I interferons (IFN-I) and IFN-γ and to benefit from inflammasome-mediated antagonism of IFn-I, highlighting similarities between the immune responses against this obligate cytosolic bacterial pathogen and those that target viral pathogens.
Journal ArticleDOI
Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity
James A. D. Good,Jim Silver,Carlos Núñez-Otero,Wael Bahnan,K. Syam Krishnan,Olli Salin,Patrik Engström,Richard Svensson,Per Artursson,Åsa Gylfe,Sven Bergström,Fredrik Almqvist +11 more
TL;DR: A class of small molecules is presented to enable the development of specific treatments for C. trachomatis without host cell toxicity and a highly active fluorescent analogue 37 localized inside the parasitiphorous inclusion, indicative of a specific targeting of bacterial components.
Journal ArticleDOI
Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol.
TL;DR: It is suggested that although actin polymerisation protects the bacterial surface from autophagic recognition, actin‐based motility allows escape of L. monocytogenes from Autophagic membranes in the macrophage cytosol.
Journal ArticleDOI
Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity
Patrik Engström,Bidong D. Nguyen,Johan Normark,Ingela Nilsson,Robert J. Bastidas,Åsa Gylfe,Mikael Elofsson,Kenneth A. Fields,Raphael H. Valdivia,Hans Wolf-Watz,Sven Bergström +10 more
TL;DR: It is found that the iron-saturated SAH INP0341 (IS-INP 0341) specifically affects C. trachomatis infectivity with reduced generation of infectious elementary body (EB) progeny.