Paul Alvinerie

TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.

TL;DR: Microsomes from patients treated with barbiturates and benzodiazepines increased the formation of metabolite M4 to the level of metabolites M5, demonstrating that drug interactions could modify the human metabolism of taxol.

TL;DR: Data strongly suggested that the structure of the lateral chain and the nature of substituent in position 10 play an important role in determining the regioselective oxidation by P450 proteins and modulate the reaction rate by human liver microsomes.

TL;DR: The biliary excretion of Taxol has been studied in rats and in a human patient receiving Taxol in a phase I trial, and the chemical structures of four of the rat metabolites and three of the human metabolites have been identified.

TL;DR: A high CYP3A4 activity in the patient is consistent with the repeated administration of methylprednisolone for 14 days before paclitaxel treatment, a compound known to induce the CYP1A isoform, and with the increased ratio of 6beta-hydroxycortisol/ cortisol in urine, an index of CYP2A activity.