Paul Bamborough

TL;DR: The benzimidazole derivatives are potentially useful in the treatment of diseases associated with inappropriate I-kappa-B kinase-3 (IKK3) as discussed by the authors.

TL;DR: The optimisation of a series of phenyl sulfonamides which exhibit a novel mode of binding to non-Bromodomain and Extra Terminal Domain (non-BET) bromidomains through displacement of a normally conserved network of four water molecules is reported.

TL;DR: Small-molecule inhibitors that remove nuclear foci and have beneficial effects in the HSALR mouse model, reducing transgene expression, leading to improvements in myotonia, splicing, and centralized nuclei are reported.

TL;DR: The p38 inhibitors of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 activity or mediated by cytokines produced by the activity of P38 as discussed by the authors.

TL;DR: An aminoxadiazole with an antiparasitic profile comparable with artemisinin is identified from the GSK antimalarial set, with no cross-resistance in a resistant strains panel and a potential new mode of action.