P
Paul Brazeau
Researcher at McGill University
Publications - 56
Citations - 3619
Paul Brazeau is an academic researcher from McGill University. The author has contributed to research in topics: Somatostatin & Prolactin. The author has an hindex of 32, co-authored 56 publications receiving 3597 citations. Previous affiliations of Paul Brazeau include Montreal Neurological Institute and Hospital & Montreal General Hospital.
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Depressant action of TRH, LH-RH and somatostatin on activity of central neurones.
TL;DR: It is found that TRH, LH–RH and somatostatin have a potent depressant action on the activity of neurones at several levels (cerebral and cerebellar cortex brain stem and hypothalamus) of the neural axis.
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Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.
Nicholas Ling,Frederick Esch,Peter Bohlen,Paul Brazeau,William B. Wehrenberg,Roger Guillemin +5 more
TL;DR: The hypophysiotropic peptide, growth hormone-releasing factor (GRF), was isolated from human hypothalamic-hypophysial tissues by means of acid extraction, immunoaffinity chromatography, gel filtration, and two steps of reverse-phase high-performance liquid chromatography.
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Analysis of the disruption in hypothalamic-pituitary regulation in rats treated neonatally with monosodium L-glutamate (MSG): evidence for the involvement of tuberoinfundibular cholinergic and dopaminergic systems in neuroendocrine regulation.
Charles B. Nemeroff,Richard J. Konkol,Garth Bissette,W.W. Youngblood,Joseph B. Martin,Paul Brazeau,Michael S. Rone,Arthur J. Prange,George R. Breese,John S. Kizer +9 more
TL;DR: The biochemical basis for the MSG-induced endocrine dysfunction has been examined and the findings of note are normal serum levels of TSH and LH despite hypothyroidism and gonadal atrophy, and significantly reduced serum GH levels in both males and females.
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Subcellular distribution of radioimmunoassayable somatostatin in rat brain.
Jacques Epelbaum,Jacques Epelbaum,Paul Brazeau,Paul Brazeau,David Tsang,David Tsang,James R. Brawer,James R. Brawer,Joseph B. Martin,Joseph B. Martin +9 more
TL;DR: It is hypothesized that somatostatin, in addition to being released into blood vessels of the median eminence, may also be liberated from nerve terminals in other brain regions.
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Antiserum to somatostatin reverses starvation-induced inhibition of growth hormone but not insulin secretion.
TL;DR: It is suggested that circulating SRIF is a physiological regulator of starvation-induced GH suppression but is not involved in mediating the inhibition of insulin.