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William B. Wehrenberg
Researcher at University of Wisconsin–Milwaukee
Publications - 139
Citations - 7375
William B. Wehrenberg is an academic researcher from University of Wisconsin–Milwaukee. The author has contributed to research in topics: Growth hormone secretion & Somatostatin. The author has an hindex of 44, co-authored 139 publications receiving 7332 citations. Previous affiliations of William B. Wehrenberg include Clemson University & Salk Institute for Biological Studies.
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Journal ArticleDOI
Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
Roger Guillemin,Paul Brazeau,Peter Bohlen,Frederick Esch,Nicholas Ling,William B. Wehrenberg +5 more
TL;DR: A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly and has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone.
Book ChapterDOI
Molecular characterization of fibroblast growth factor: distribution and biological activities in various tissues.
Andrew Baird,Frederick Esch,Pierre Mormede,Naoto Ueno,Nicholas Ling,Peter Bohlen,Shao-Yao Ying,William B. Wehrenberg,Roger Guillemin +8 more
TL;DR: The results presented in the chapter suggest that heretofore unidentified biologic activities may be related if not identical to acidic and basic FGFs.
Journal ArticleDOI
Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.
Nicholas Ling,Frederick Esch,Peter Bohlen,Paul Brazeau,William B. Wehrenberg,Roger Guillemin +5 more
TL;DR: The hypophysiotropic peptide, growth hormone-releasing factor (GRF), was isolated from human hypothalamic-hypophysial tissues by means of acid extraction, immunoaffinity chromatography, gel filtration, and two steps of reverse-phase high-performance liquid chromatography.
Journal ArticleDOI
Immunohistochemical detection of growth hormone-releasing factor in brain
Bertrand Bloch,Paul Brazeau,Nicholas Ling,Peter Bohlen,Frederick Esch,William B. Wehrenberg,Robert Benoit,Floyd E. Bloom,Roger Guillemin +8 more
TL;DR: It is reported here that antisera against the hpGRF1–40 peptide specifically stain neuronal cell bodies in the arcuate nucleus of the primate hypothalamus, with fibres projecting to the median eminence and ending in contact with portal vessels, which provides evidence that hypothalamic GRF is very similar, if not identical, tohpGRF.
Journal ArticleDOI
Effect of Sex Steroids on β-Endorphin in Hypophyseal Portal Blood
TL;DR: The effects of estradiol and progesterone replacement on portal blood β-EP in ovariectomized monkeys was examined and high levels ofβ-EP were measured in all 13 portal blood samples collected from 4 ovariectorized monkeys.