P
Paul D. Fraser
Researcher at Royal Holloway, University of London
Publications - 202
Citations - 14874
Paul D. Fraser is an academic researcher from Royal Holloway, University of London. The author has contributed to research in topics: Carotenoid & Phytoene. The author has an hindex of 55, co-authored 184 publications receiving 12821 citations. Previous affiliations of Paul D. Fraser include University of London & Spanish National Research Council.
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Journal ArticleDOI
The biosynthesis and nutritional uses of carotenoids.
Paul D. Fraser,Peter M. Bramley +1 more
TL;DR: The aim of this article is to review the current understanding of carotenoid formation, to explain the perceived benefits ofcarotenoids in the diet and review the efforts that have been made to increase carotanoids in certain crop plants.
Journal ArticleDOI
Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS
John M. Halket,Daniel Waterman,Anna Przyborowska,Raj K. P. Patel,Paul D. Fraser,Peter M. Bramley +5 more
TL;DR: The potential of derivatization for metabolic profiling in LC/MS is demonstrated by the enhanced analysis of plant extracts, including the potential to measure volatile acids such as formic acid, difficult to achieve by GC/MS.
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Carotenoid Biosynthesis during Tomato Fruit Development (Evidence for Tissue-Specific Gene Expression)
TL;DR: The results suggest that transcription of Psy and Pds is regulated developmentally, with expression being considerably elevated in chromoplast-containing tissues, and lends support to the hypothesis of divergent genes encoding these enzymes.
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Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner.
Paul D. Fraser,Susanne Römer,Cathie A. Shipton,Philippa B. Mills,Joy W. Kiano,Norihiko Misawa,Rachel Drake,Wolfgang Schuch,Peter M. Bramley +8 more
TL;DR: Metabolic control analysis suggests that the presence of an additional phytoene synthase reduces the regulatory effect of this step over the carotenoid pathway, and the activities of other enzymes in the pathway (isopentenyl diphosphate isomerase, geranylgeranyl diph phosphate synthase, and incorporation of isopentanyl dphosphate into phy toene) were not significantly altered.
Journal ArticleDOI
Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes
Ganga Rao Davuluri,Ageeth van Tuinen,Paul D. Fraser,Alessandro Manfredonia,Robert Newman,Diane Burgess,David A. Brummell,Stephen R. King,Joe Palys,John Uhlig,Peter M. Bramley,Henk M. J. Pennings,Chris Bowler +12 more
TL;DR: Results demonstrate that manipulation of a plant regulatory gene can simultaneously influence the production of several phytonutrients generated from independent biosynthetic pathways, and provide a novel example of the use of organ-specific gene silencing to improve the nutritional value of plant-derived products.