Paul G. Grothaus

TL;DR: This work presents a meta-analysis of the “Metagenome” of Cyanophytes and Marine Microbes, which highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.

TL;DR: The discovery of a selective, irreversible Btk inhibitor and its efficacy in an animal model of rheumatoid arthritis is described.

TL;DR: Immunoassay techniques are currently being used to screen extracts of Taxomyces andreanae for new taxanes, and to determine if other endophytic fungi are taxol producers, which appears to produce taxol and other taxanes in de novo fashion when grown in semi-synthetic liquid media.

TL;DR: The application of new techniques and methodology developed through the impressive progress made in multidisciplinary, natural product-related research in recent years should aid substantially in expediting the discovery and development process.

TL;DR: The NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions.