G
Gary S. Bignami
Researcher at University of Trieste
Publications - 25
Citations - 1296
Gary S. Bignami is an academic researcher from University of Trieste. The author has contributed to research in topics: Palytoxin & Taxus brevifolia. The author has an hindex of 15, co-authored 25 publications receiving 1242 citations.
Papers
More filters
Journal ArticleDOI
The search for a taxol-producing microorganism among the endophytic fungi of the Pacific yew, Taxus brevifolia.
TL;DR: Immunoassay techniques are currently being used to screen extracts of Taxomyces andreanae for new taxanes, and to determine if other endophytic fungi are taxol producers, which appears to produce taxol and other taxanes in de novo fashion when grown in semi-synthetic liquid media.
Journal ArticleDOI
Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys.
David E. Clements,Beth-Ann Coller,Michael M. Lieberman,Steven Ogata,Gordon V.L. Wang,Kent E. Harada,J. Robert Putnak,John M. Ivy,Michael Mcdonell,Gary S. Bignami,Iain Peters,Julia Leung,Carolyn Weeks-Levy,Eileen T. Nakano,Tom Humphreys +14 more
TL;DR: Results support the development of a dengue virus tetravalent vaccine based on the four 80E subunits produced in the Drosophila S2 cell expression system, which are highly immunogenic and capable of eliciting protective responses in both mice and monkeys.
Journal ArticleDOI
An evaluation of dengue type-2 inactivated, recombinant subunit, and live-attenuated vaccine candidates in the rhesus macaque model.
J. Robert Putnak,Beth-Ann Coller,Gerald Voss,David W. Vaughn,David E. Clements,Iain Peters,Gary S. Bignami,Hou-Shu Houng,Robert Chung-Ming Chen,David A. Barvir,Jitvimol Seriwatana,Sylvie Cayphas,Nathalie Garçon,Dirk Gheysen,Niranjan Kanesa-thasan,Mike McDonell,Tom Humphreys,Kenneth H. Eckels,Jean-Paul Prieels,Bruce L. Innis,Bruce L. Innis +20 more
TL;DR: Several groups exhibited nearly complete protection against viremia by bioassay, although there was evidence for challenge virus replication by Taqmantrade mark and immunological assays, and none of the vaccines conferred sterile immunity.
Journal ArticleDOI
A rapid and sensitive hemolysis neutralization assay for palytoxin
TL;DR: Hemolysis by palytoxin was time- and temperature-dependent, with a 24 hr detection limit of 1 pg/ml, and the assay selectively detected palyToxin in a crude extract of Palythoa tuberculosa.
Journal ArticleDOI
Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from Hawaiian Palythoa Subspecies
Patrizia Ciminiello,Carmela Dell'Aversano,Emma Dello Iacovo,Ernesto Fattorusso,Martino Forino,Laura Grauso,Luciana Tartaglione,Chiara Florio,Paola Lorenzon,Marco De Bortoli,Aurelia Tubaro,Mark Poli,Gary S. Bignami +12 more
TL;DR: Functional studies on this new palytoxin-like compound suggest that the new palitoxin analogue and palyToxin itself present similar biological activities.