NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening
Christopher C. Thornburg,John R. Britt,Jason R. Evans,Rhone K. Akee,JA Whitt,Spencer K. Trinh,Matthew J. Harris,Jerell R. Thompson,Teresa L. Ewing,Suzanne M. Shipley,Paul G. Grothaus,David J. Newman,Joel P. Schneider,Tanja Grkovic,Barry R. O'Keefe +14 more
TLDR
The NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions.Abstract:
The US National Cancer Institute’s (NCI) Natural Product Repository is one of the world’s largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations, the NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural produ...read more
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Journal ArticleDOI
Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes
TL;DR: The origin and the variety of natural chemical diversity as well as the strategies to having the potential to embrace this diversity are discussed, and alternative ways to access and explore part of this chemical diversity with in vitro cultures are suggested.
Journal ArticleDOI
Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery
TL;DR: Recent studies that have the potential to improve the efficiency of NP prioritisation and to accelerate the targeted isolation of key NPs are examined, hoping to return NPs back to an exciting era of development.
Journal ArticleDOI
CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines.
Vinodh N. Rajapakse,Augustin Luna,Mihoko Yamade,Lisa Loman,Sudhir Varma,Margot Sunshine,Francesco Iorio,Fabricio G. Sousa,Fathi Elloumi,Mirit I. Aladjem,Anish Thomas,Chris Sander,Kurt W. Kohn,Cyril H. Benes,Mathew J. Garnett,William C. Reinhold,Yves Pommier +16 more
TL;DR: The value of CellMinerCDB in selecting drugs with reproducible activity is demonstrated, the dominant role of SLFN11 for drug response is expanded, and novel response determinants and genomic signatures for topoisomerase inhibitors and schweinfurthins are presented.
Journal ArticleDOI
The Symbiotic Relationship Between Drug Discovery and Organic Chemistry.
Oleksandr O. Grygorenko,Oleksandr O. Grygorenko,Dmitriy M. Volochnyuk,Dmitriy M. Volochnyuk,Dmitriy M. Volochnyuk,Sergey V. Ryabukhin,Sergey V. Ryabukhin,Duncan B. Judd +7 more
TL;DR: Criteria for a high-quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry, diversity-, biology-, lead-, or fragment-oriented syntheses, DNA-encoded libraries etc.) are critically surveyed.
Journal ArticleDOI
Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi
Melanie-Jayne R. Howes,Melanie-Jayne R. Howes,Cassandra L. Quave,Jérôme Collemare,Evangelos C. Tatsis,Danielle Twilley,Ermias Lulekal,Andrew Farlow,Liping Li,María‐Elena Cazar,Danna J. Leaman,Thomas A.K. Prescott,William Milliken,Cathie Martin,Marco Nuno De Canha,Namrita Lall,Namrita Lall,Namrita Lall,Haining Qin,Barnaby E. Walker,Carlos A. Vásquez-Londoño,Bob Allkin,Malin C. Rivers,Monique S. J. Simmonds,Elizabeth Bell,Alex Battison,Juri Felix,Félix Forest,Christine Leon,China Williams,Eimear Nic Lughadha +30 more
TL;DR: Current and emerging scientific approaches are presented, to uncover and preserve nature-based health solutions for the future, through harmonization with biodiversity conservation strategies.
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