R
Rhone K. Akee
Researcher at Leidos
Publications - 4
Citations - 135
Rhone K. Akee is an academic researcher from Leidos. The author has contributed to research in topics: Erythrophleum suaveolens & Strophanthin. The author has an hindex of 3, co-authored 4 publications receiving 75 citations. Previous affiliations of Rhone K. Akee include National Institutes of Health.
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NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening
Christopher C. Thornburg,John R. Britt,Jason R. Evans,Rhone K. Akee,JA Whitt,Spencer K. Trinh,Matthew J. Harris,Jerell R. Thompson,Teresa L. Ewing,Suzanne M. Shipley,Paul G. Grothaus,David J. Newman,Joel P. Schneider,Tanja Grkovic,Barry R. O'Keefe +14 more
TL;DR: The NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions.
Journal ArticleDOI
National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library
Tanja Grkovic,Rhone K. Akee,Christopher C. Thornburg,Spencer K. Trinh,John R. Britt,Matthew J. Harris,Jason R. Evans,Unwoo Kang,Susan M. Ensel,Curtis J. Henrich,Kirk R. Gustafson,Joel P. Schneider,Barry R. O'Keefe +12 more
TL;DR: Overall, the rapid second-stage purification conserves extract mass, requires much less chemist time, and introduces knowledge of structure early in the isolation workflow.
Journal ArticleDOI
The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species.
Min He,Tanja Grkovic,Jason R. Evans,Christopher C. Thornburg,Rhone K. Akee,Jerell R. Thompson,JA Whitt,Matthew J. Harris,Jasmine A. Loyal,John R. Britt,Libin Jia,Jeffrey D. White,David J. Newman,Barry R. O'Keefe +13 more
TL;DR: The methodology used to generate the prototype Traditional Chinese Medicine plant extract library and the preliminary assessment of the anti-proliferative activity of this crude extract library in NCI-60 human cancer cell lines screen are presented.
Journal ArticleDOI
Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.
Tanja Grkovic,Jason R. Evans,Rhone K. Akee,Liang Guo,Myrtle Davis,Johnson Jato,Paul G. Grothaus,Michelle Ahalt-Gottholm,Melinda G. Hollingshead,Jerry M. Collins,David J. Newman,Barry R. O'Keefe +11 more
TL;DR: Two new cassaine-type diterpenoids, namely erythrofordins D and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity and showed similar NCI-60 response profiles to the known cardiac glycosides hyrcanoside and strophanthin.