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David J. Porteous

Researcher at University of Edinburgh

Publications -  764
Citations -  60267

David J. Porteous is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 109, co-authored 718 publications receiving 48191 citations. Previous affiliations of David J. Porteous include Western General Hospital & University of Glasgow.

Papers
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Naomi R. Wray, +262 more
- 26 Apr 2018 - 
TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

James J. Lee, +94 more
- 23 Jul 2018 - 
TL;DR: A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance ineducational attainment and 7–10% ofthe variance in cognitive performance, which substantially increases the utility ofpolygenic scores as tools in research.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

David M. Howard, +45 more
- 30 Jan 2019 - 
TL;DR: A genetic meta-analysis of depression found 269 associated genes that highlight several potential drug repositioning opportunities, and relationships with depression were found for neuroticism and smoking.
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Disruption of two novel genes by a translocation co-segregating with schizophrenia

J. Kirsty Millar, +10 more
- 22 May 2000 - 
TL;DR: Observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness.