P
Paul Leibowitz
Publications - 9
Citations - 2831
Paul Leibowitz is an academic researcher. The author has contributed to research in topics: Transgene & Amyloid precursor protein. The author has an hindex of 6, co-authored 9 publications receiving 2763 citations.
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Journal ArticleDOI
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Dora Games,David S. Adams,Ree Alessandrini,Robin Barbour,Patricia Borthelette,Catherine Blackwell,Tony Carr,J. C. Clemens,Thomas Donaldson,Frances Gillespie,Terry Guido,Stephanie Hagopian,Kelly Johnson-Wood,Karen Khan,Michael K. Lee,Paul Leibowitz,Ivan Lieberburg,Sheila P. Little,Eliezer Masliah,Lisa McConlogue,Martin Montoya-Zavala,Lennart Mucke,Lisa Paganini,Elizabeth Penniman,Michael Power,Dale Schenk,Peter Seubert,Ben W. Snyder,Ferdie Soriano,Hua Tan,James Vitale,Sam Wadsworth,Ben Wolozin,Jun Zhao +33 more
TL;DR: Transgenic mice that express high levels of human mutant APP support a primary role for APP/Aβ in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.
Patent
Transgenic mouse assay for compounds affecting amyloid protein processing
TL;DR: In this paper, the authors describe the construction of transgenic animal models for testing potential treatments for Alzheimer's disease, based on expression of all three forms of the β-amyloid precursor protein (APP), APP 695, APP 751, and APP 770 ), as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer disease (FAD) mutations at amino acid 717, and predicted mutations in the APP gene.
Journal ArticleDOI
Developmental and tissue-specific expression of human CD4 in transgenic rabbits.
Ben W. Snyder,James Vitale,Patrice Milos,Joe Gosselin,Frances Gillespie,Karl M. Ebert,Bishop F. Hague,Thomas J. Kindt,Sam Wadsworth,Paul Leibowitz +9 more
TL;DR: Results extend to rabbits the authors' previous observation that this transgene contains the sequence elements required for high‐level expression in the appropriate cells of transgenic mice, and suggest that the hCD4 transgenic rabbits described herein will have an increased susceptibility to HIV‐1 infection.
Patent
Transgenic mouse expressing APP770
TL;DR: In this article, the authors describe the construction of transgenic mouse models for testing potential treatments for Alzheimer's disease, based on expression of all three forms of the β-amyloid precursor protein (APP), APP 695, APP 751, and APP 770 ), as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer's Disease (FAD) mutations at amino acid 717, and predicted mutations in the APP gene.
Patent
Producing cells for transplantation to reduce host rejection and resulting cells
TL;DR: In this article, a method for treating cells with E19 protein in order to alter the presentation of MHC class I cell surface antigens on these cells and thereby allow introduction of these cells into a recipient organism while reducing transplant rejection by the recipient organism's immune system is described.