J
James Vitale
Researcher at Millennium Pharmaceuticals
Publications - 4
Citations - 2895
James Vitale is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Transgene & Genetically modified mouse. The author has an hindex of 3, co-authored 4 publications receiving 2825 citations.
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Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Dora Games,David S. Adams,Ree Alessandrini,Robin Barbour,Patricia Borthelette,Catherine Blackwell,Tony Carr,J. C. Clemens,Thomas Donaldson,Frances Gillespie,Terry Guido,Stephanie Hagopian,Kelly Johnson-Wood,Karen Khan,Michael K. Lee,Paul Leibowitz,Ivan Lieberburg,Sheila P. Little,Eliezer Masliah,Lisa McConlogue,Martin Montoya-Zavala,Lennart Mucke,Lisa Paganini,Elizabeth Penniman,Michael Power,Dale Schenk,Peter Seubert,Ben W. Snyder,Ferdie Soriano,Hua Tan,James Vitale,Sam Wadsworth,Ben Wolozin,Jun Zhao +33 more
TL;DR: Transgenic mice that express high levels of human mutant APP support a primary role for APP/Aβ in the genesis of AD and could provide a preclinical model for testing therapeutic drugs.
Journal ArticleDOI
The mahogany protein is a receptor involved in suppression of obesity
Deborah L. Nagle,Sonja H. McGrail,James Vitale,Elizabeth A. Woolf,Barry J. Dussault,Lisa DiRocco,Lisa Holmgren,Jill Montagno,Peer Bork,Dennis Huszar,Victoria Fairchild-Huntress,Pei Ge,John Keilty,Chris Ebeling,Linda Baldini,Julie Gilchrist,Paul Burn,George A. Carlson,Karen J. Moore +18 more
TL;DR: This study represents the first positional cloning of a suppressor gene in the mouse, and proposes two potential, alternative modes of action for mahogany: one draws parallels with the mechanism of action of low-affinity proteoglycan receptors such as fibroblast growth factor and transforming growth factor-β, and the other suggests that Mahogany itself is a signalling receptor.
Journal ArticleDOI
Developmental and tissue-specific expression of human CD4 in transgenic rabbits.
Ben W. Snyder,James Vitale,Patrice Milos,Joe Gosselin,Frances Gillespie,Karl M. Ebert,Bishop F. Hague,Thomas J. Kindt,Sam Wadsworth,Paul Leibowitz +9 more
TL;DR: Results extend to rabbits the authors' previous observation that this transgene contains the sequence elements required for high‐level expression in the appropriate cells of transgenic mice, and suggest that the hCD4 transgenic rabbits described herein will have an increased susceptibility to HIV‐1 infection.