P
Paul M. Tulkens
Researcher at Université catholique de Louvain
Publications - 381
Citations - 19031
Paul M. Tulkens is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Aminoglycoside & Nephrotoxicity. The author has an hindex of 69, co-authored 377 publications receiving 17710 citations. Previous affiliations of Paul M. Tulkens include University College London & Catholic University of Leuven.
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Journal ArticleDOI
Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic
Houssein Chalhoub,Daniel Pletzer,Helge Weingart,Yvonne Braun,Michael M. Tunney,J. Stuart Elborn,Hector Rodriguez-Villalobos,Patrick Plésiat,Barbara C. Kahl,Olivier Denis,Mathias Winterhalter,Paul M. Tulkens,Françoise Van Bambeke +12 more
TL;DR: Clinical-exploitable MICs are shown on a non-negligible proportion of CF isolates, explained by a wide diversity of mutations in mexA and/or mexB, contributing to increase the understanding of MexAB-OprM functionality and help delineating how antibiotics interact with MexA and MexB.
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Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts)
Maritza Barcia-Macay,Fatima Mouaden,Marie-Paule Mingeot-Leclercq,Paul M. Tulkens,Françoise Van Bambeke +4 more
TL;DR: Telavancin is taken up by eukaryotic cells and localizes in lysosomes, causing mild morphological alterations without evidence of lipid metabolism alterations, and these data support the observations that telavANCin is active against intracellular S. aureus.
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Safety, pharmacokinetics and efficacy of once-a-day netilmicin and amikacin versus their conventional schedules in patients suffering from pelvic inflammatory disease.
S. Ibrahim,M P Derde,L. Kaufman,F Clerckx-Braun,P. Jacqmin,Brulein,Jacques Donnez,Paul M. Tulkens +7 more
TL;DR: The data suggest that the qd schedule of AK and of NT is as efficacious as their cs schedules, and causes less renal and auditory alterations.
Journal ArticleDOI
Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
TL;DR: The three approaches indicate that aminoglycosides induce liposomes aggregation, but not fusion, which could rationally be screened for new derivatives by the methods applied here.